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• W1908191710 abstract "Revisamos brevemente algunos aspectos del movimiento de agua en las celulas renales. Primero se muestran estudios de Biofisica que llevan a concluir que existen poros acuosos perforando las membranas celulares de los tubulos renales proximales; y a poder calcular las dimensiones del filtro de selectividad de un “canal equivalente” para el paso de agua de ~ 4.5 A de diametro y de una longitud equivalente de ~ 10 – 20 A. Como las moleculas de agua tienen un diametro de 3 A, solo 4 a 6 moleculas de agua pueden acomodarse en fila india dentro del filtro de selectividad. Estudios de biologia molecular han aclarado la secuencia de aminoacidos de las proteinas (de 28 kD) que forman el canal. Se denominan Aquaporinas (AQPs). Se conocen unas 10. Revisamos la estructura tridimensional de AQP-1, presente en los tubulos renales proximales. Tambien la relacion entre diabetes insipida y AQP-2, en que hay mala funcion de los mecanismos de concentracion urinaria. Finalmente se hace un arbol filogenetico de las AQPs en donde se ve que hay AQPs muy antiguas en bacterias, plantas e insectos. La RP-mip una AQP de los tubulos de malpighi del Rhodnius es de las mas antiguas de la escala biologica. Las AQPs de mamifero son mucho mas recientes. ABSTRACT This is a short overview of some aspects of water movements across kidney cells. It begins with the biophysical methods that lead to the conclusion that there are indeed water channels piercing the kidney proximal tubule cell membranes. These methods allow to calculate (a) the diameter of the selectivity filter of an “equivalent water channel” of ~ 4.5 A, and (b) its “equivalent length” of ~ 10 – 20 A. (c) As water molecules have a diameter of 3 A, water molecules must line up within the selectivity filter as an Indian file 4 to 6 molecules long. Molecular biology studies have uncovered the aminoacid sequence of the 28 kDprotein molecules that form the water channels. They are called Aquaporins (AQPs). Some 10 are known. AQP-1 is present in the kidney proximal tubule. The tri-dimensional AQP-1 structure is reviewed, and the relation between diabetes insipidus and genetic structural failures of AQP-2 which lead to malfunction of the urinary concentrating mechanisms. Finally we review the molecular structure of a newly found AQP called RP-mip, which is present in Rhodnius prolixus malpighian tubules. A philogenetic tree indicates it to be one of the oldest AQPs. Mammalian AQPs are more recent in the biological scale." @default.
• W1908191710 created "2016-06-24" @default.
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• W1908191710 date "2002-01-01" @default.
• W1908191710 modified "2023-09-23" @default.
• W1908191710 title "Canales de Agua (Aquaporinas) y Riñón" @default.
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• W1908191710 cites W1829487208 @default.
• W1908191710 cites W1874223008 @default.
• W1908191710 cites W1903404096 @default.
• W1908191710 cites W1918420740 @default.
• W1908191710 cites W1947778485 @default.
• W1908191710 cites W1963754359 @default.
• W1908191710 cites W1970810469 @default.
• W1908191710 cites W1970971540 @default.
• W1908191710 cites W1971027475 @default.
• W1908191710 cites W1971684396 @default.
• W1908191710 cites W1974392821 @default.
• W1908191710 cites W1975745283 @default.
• W1908191710 cites W1977487853 @default.
• W1908191710 cites W1980089653 @default.
• W1908191710 cites W1987972604 @default.
• W1908191710 cites W1988412215 @default.
• W1908191710 cites W1988490992 @default.
• W1908191710 cites W1988585554 @default.
• W1908191710 cites W1990144236 @default.
• W1908191710 cites W1994825180 @default.
• W1908191710 cites W1995178724 @default.
• W1908191710 cites W1996196738 @default.
• W1908191710 cites W2002523635 @default.
• W1908191710 cites W2003879331 @default.
• W1908191710 cites W2004264820 @default.
• W1908191710 cites W2004517356 @default.
• W1908191710 cites W2012897198 @default.
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• W1908191710 cites W2027156597 @default.
• W1908191710 cites W2027740361 @default.
• W1908191710 cites W2028237738 @default.
• W1908191710 cites W2028242767 @default.
• W1908191710 cites W2029785545 @default.
• W1908191710 cites W2032789959 @default.
• W1908191710 cites W2038807786 @default.
• W1908191710 cites W2045871471 @default.
• W1908191710 cites W2048785411 @default.
• W1908191710 cites W2049745117 @default.
• W1908191710 cites W2052599381 @default.
• W1908191710 cites W2052922251 @default.
• W1908191710 cites W2061650263 @default.
• W1908191710 cites W2071051054 @default.
• W1908191710 cites W2071358352 @default.
• W1908191710 cites W2075873002 @default.
• W1908191710 cites W2078482870 @default.
• W1908191710 cites W2081460613 @default.
• W1908191710 cites W2081752448 @default.
• W1908191710 cites W2081911678 @default.
• W1908191710 cites W2084935848 @default.
• W1908191710 cites W2086372236 @default.
• W1908191710 cites W2088396659 @default.
• W1908191710 cites W2090144945 @default.
• W1908191710 cites W2091266639 @default.
• W1908191710 cites W2114634962 @default.
• W1908191710 cites W2131310812 @default.
• W1908191710 cites W2135597817 @default.
• W1908191710 cites W2137408480 @default.
• W1908191710 cites W2141207242 @default.
• W1908191710 cites W2141659719 @default.
• W1908191710 cites W2142432100 @default.
• W1908191710 cites W2152907424 @default.
• W1908191710 cites W2152908352 @default.
• W1908191710 cites W2154312242 @default.
• W1908191710 cites W2158240059 @default.
• W1908191710 cites W2162327349 @default.
• W1908191710 cites W2259875908 @default.
• W1908191710 cites W2325648750 @default.
• W1908191710 cites W2330748119 @default.
• W1908191710 cites W2332525600 @default.
• W1908191710 cites W2403526127 @default.
• W1908191710 cites W2416538760 @default.
• W1908191710 cites W2484328436 @default.
• W1908191710 cites W436674532 @default.
• W1908191710 cites W52234258 @default.
• W1908191710 cites W53682016 @default.
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