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- W1908265276 abstract "Background: The cysteinyl leukotrienes (CysLTs) play a key role in the pathophysiology of asthma. In addition to functioning as potent bronchoconstrictors, CysLTs contribute to airway inflammation through eosinophil and neutrophil chemotaxis, plasma exudation and mucus secretion. Aim: To test the activity of the dual CysLT1/2 antagonist, ONO-6950, against allergen-induced airway responses. Methods: Subjects with documented allergen-induced early (EAR) and late (LAR) asthmatic responses were randomized in a 3-way crossover study to receive ONO -6950 (200 mg) or montelukast (10 mg) or placebo q.d. on Days 1-8 of the 3 treatment periods. Allergen was inhaled on Day 7 and forced expiratory volume in 1 second (FEV 1 ) was measured for 7 hours following challenge. Sputum eosinophils, and airway hyperresponsiveness were measured before and after allergen challenge. The primary outcome was the effect of ONO-6950 versus placebo on the EAR and LAR. Results: Twenty-five non-smoking subjects with mild allergic asthma were enrolled and 20 subjects completed all 3 treatment periods per protocol. ONO-6950 was well tolerated. Compared to placebo, ONO-6950 significantly attenuated the maximum % fall in FEV 1 and area under the %FEV 1 /time curve during the early and late asthmatic responses (p Conclusions: Attenuation of EAR, LAR, and airway inflammation is consistent with CysLT1 blockade. Whether dual CysLT1/2 antagonism offers additional benefit for treatment of asthma requires further study. Funded by ONO Pharmaceutical Co., Ltd., and AllerGen NCE Inc." @default.
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- W1908265276 date "2014-09-01" @default.
- W1908265276 modified "2023-09-29" @default.
- W1908265276 title "Late-breaking abstract: Effects of a dual CysLT1/2 antagonist, ONO-6950, on allergen-induced airway responses in subjects with mild allergic asthma" @default.
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