Matches in SemOpenAlex for { <https://semopenalex.org/work/W190829892> ?p ?o ?g. }
- W190829892 endingPage "310" @default.
- W190829892 startingPage "249" @default.
- W190829892 abstract "Primary (nonmotile) cilia are currently enjoying a renaissance in light of novel ascribed functions ranging from mechanosensory to signal transduction. Their importance for key developmental pathways such as Sonic Hedgehog (Shh) and Wnt is beginning to emerge. The function of nodal cilia, for example, is vital for breaking early embryonic symmetry, Shh signaling is important for tissue morphogenesis and successful Wnt signaling for organ growth and differentiation. When ciliary function is perturbed, photoreceptors may die, kidney tubules develop cysts, limb digits multiply and brains form improperly. The etiology of several uncommon disorders has recently been associated with cilia dysfunction. The causative genes are often similar and their cognate proteins certainly share cellular locations and/or pathways. Animal models of ciliary gene ablation such as Ift88, Kif3a, and Bbs have been invaluable for understanding the broad function of the cilium. Herein, we describe the wealth of information derived from the study of the ciliopathies and their animal models. “This world, after all our science and sciences, is still a miracle; wonderful, inscrutable, magical and more, to whosoever will think of it.” (Thomas Carlyle)" @default.
- W190829892 created "2016-06-24" @default.
- W190829892 creator A5001912513 @default.
- W190829892 creator A5001974951 @default.
- W190829892 creator A5068665016 @default.
- W190829892 date "2008-01-01" @default.
- W190829892 modified "2023-10-05" @default.
- W190829892 title "Chapter 5 Modeling Ciliopathies" @default.
- W190829892 cites W145743825 @default.
- W190829892 cites W1487123743 @default.
- W190829892 cites W1492104840 @default.
- W190829892 cites W1518382324 @default.
- W190829892 cites W1552907768 @default.
- W190829892 cites W1595325053 @default.
- W190829892 cites W1638661036 @default.
- W190829892 cites W1693754698 @default.
- W190829892 cites W1868335994 @default.
- W190829892 cites W1897871655 @default.
- W190829892 cites W1962669878 @default.
- W190829892 cites W1964144242 @default.
- W190829892 cites W1964853850 @default.
- W190829892 cites W1965597819 @default.
- W190829892 cites W1966166788 @default.
- W190829892 cites W1966685035 @default.
- W190829892 cites W1966978229 @default.
- W190829892 cites W1967695632 @default.
- W190829892 cites W1969212379 @default.
- W190829892 cites W1971060771 @default.
- W190829892 cites W1971197630 @default.
- W190829892 cites W1971462660 @default.
- W190829892 cites W1974601240 @default.
- W190829892 cites W1975679481 @default.
- W190829892 cites W1976197160 @default.
- W190829892 cites W1976421227 @default.
- W190829892 cites W1976588897 @default.
- W190829892 cites W1976708316 @default.
- W190829892 cites W1976709076 @default.
- W190829892 cites W1976989450 @default.
- W190829892 cites W1979002070 @default.
- W190829892 cites W1982168739 @default.
- W190829892 cites W1983538981 @default.
- W190829892 cites W1983575054 @default.
- W190829892 cites W1984510611 @default.
- W190829892 cites W1986687747 @default.
- W190829892 cites W1987279648 @default.
- W190829892 cites W1987806693 @default.
- W190829892 cites W1989248251 @default.
- W190829892 cites W1989280600 @default.
- W190829892 cites W1990760632 @default.
- W190829892 cites W1990997051 @default.
- W190829892 cites W1991585430 @default.
- W190829892 cites W1993802679 @default.
- W190829892 cites W1994353334 @default.
- W190829892 cites W1994578552 @default.
- W190829892 cites W1995651171 @default.
- W190829892 cites W1996445467 @default.
- W190829892 cites W1996743997 @default.
- W190829892 cites W1996788021 @default.
- W190829892 cites W1998083408 @default.
- W190829892 cites W1998854916 @default.
- W190829892 cites W2001229105 @default.
- W190829892 cites W2003260901 @default.
- W190829892 cites W2004441307 @default.
- W190829892 cites W2004945792 @default.
- W190829892 cites W2005026678 @default.
- W190829892 cites W2005619876 @default.
- W190829892 cites W2005938853 @default.
- W190829892 cites W2006399184 @default.
- W190829892 cites W2007673945 @default.
- W190829892 cites W2009045981 @default.
- W190829892 cites W2011258958 @default.
- W190829892 cites W2011409781 @default.
- W190829892 cites W2012113462 @default.
- W190829892 cites W2012954001 @default.
- W190829892 cites W2013614705 @default.
- W190829892 cites W2014080496 @default.
- W190829892 cites W2014264816 @default.
- W190829892 cites W2014604277 @default.
- W190829892 cites W2015234820 @default.
- W190829892 cites W2016268524 @default.
- W190829892 cites W2016510092 @default.
- W190829892 cites W2016559364 @default.
- W190829892 cites W2017349612 @default.
- W190829892 cites W2018924297 @default.
- W190829892 cites W2018927755 @default.
- W190829892 cites W2019866708 @default.
- W190829892 cites W2022083755 @default.
- W190829892 cites W2022409936 @default.
- W190829892 cites W2022475193 @default.
- W190829892 cites W2022768816 @default.
- W190829892 cites W2026168236 @default.
- W190829892 cites W2028651090 @default.
- W190829892 cites W2029194355 @default.
- W190829892 cites W2029279705 @default.
- W190829892 cites W2030939638 @default.
- W190829892 cites W2031964961 @default.
- W190829892 cites W2032792789 @default.
- W190829892 cites W2033137562 @default.