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• W1908431919 startingPage "165" @default.
• W1908431919 abstract "Receptor recycling plays a key role in the modulation of cellular responses to extracellular signals. The purpose of this work was to identify residues in G-protein coupled neurotensin receptors that are directly involved in recycling. Both the high affinity receptor-1 (NTR1) and the levocabastine-sensitive NTR2 are internalized after neurotensin binding. Here, we show that only the mouse NTR2 recycled to the plasma membrane, whereas the rat NTR1 and the human NTR2 did not. Using site-directed mutagenesis, we demonstrate that tyrosine 237 in the third intracellular loop is crucial for recycling of the mouse NTR2. We show that the mouse NTR2 is phosphorylated on tyrosine residues by NT. This phosphorylation is essential for receptor recycling since the tyrosine kinase inhibitor genistein blocks this process. The absence of recycling observed with the human NTR2 could be completely explained by the presence of a cysteine instead of a tyrosine in position 237. Indeed, substitution of this cysteine by a tyrosine gave a mutant receptor that has acquired the ability to recycle to the cell surface after neurotensin-induced internalization. This work demonstrates that a single tyrosine residue in the third intracellular loop of a G-protein-coupled receptor is responsible for receptor phosphorylation and represents an essential structural element for receptor recycling." @default.
• W1908431919 created "2016-06-24" @default.
• W1908431919 creator A5047800780 @default.
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• W1908431919 date "2002-01-01" @default.
• W1908431919 modified "2023-09-25" @default.
• W1908431919 title "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue" @default.
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• W1908431919 doi "https://doi.org/10.1242/jcs.115.1.165" @default.
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