FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1908457469> ?p ?o ?g. }

• W1908457469 endingPage "241" @default.
• W1908457469 startingPage "227" @default.
• W1908457469 abstract "Increasing evidence suggests that oxidative injury is involved in the pathogenesis of many age-related neurodegenerative disorders, including Alzheimer's disease (AD). Identifying the protein targets of oxidative stress is critical to determine which proteins may be responsible for the neuronal impairments and subsequent cell death that occurs in AD. In this study, we have applied a high-throughput shotgun proteomic approach to identify the targets of protein carbonylation in both aged and PS1 + AbetaPP transgenic mice. However, because of the inherent difficulties associated with proteomic database searching algorithms, several newly developed bioinformatic tools were implemented to ascertain a probability-based discernment between correct protein assignments and false identifications to improve the accuracy of protein identification. Assigning a probability to each identified peptide/protein allows one to objectively monitor the expression and relative abundance of particular proteins from diverse samples, including tissue from transgenic mice of mixed genetic backgrounds. This robust bioinformatic approach also permits the comparison of proteomic data generated by different laboratories since it is instrument- and database-independent. Applying these statistical models to our initial studies, we detected a total of 117 oxidatively modified (carbonylated) proteins, 59 of which were specifically associated with PS1 + AbetaPP mice. Pathways and network component analyses suggest that there are three major protein networks that could be potentially altered in PS1 + AbetaPP mice as a result of oxidative modifications. These pathways are 1) iNOS-integrin signaling pathway, 2) CRE/CBP transcription regulation and 3) rab-lyst vesicular trafficking. We believe the results of these studies will help establish an initial AD database of oxidatively modified proteins and provide a foundation for the design of future hypothesis driven research in the areas of aging and neurodegeneration." @default.
• W1908457469 created "2016-06-24" @default.
• W1908457469 creator A5006563536 @default.
• W1908457469 creator A5010842155 @default.
• W1908457469 creator A5032386364 @default.
• W1908457469 creator A5051732343 @default.
• W1908457469 creator A5062603565 @default.
• W1908457469 creator A5077716269 @default.
• W1908457469 creator A5080895261 @default.
• W1908457469 creator A5089219708 @default.
• W1908457469 date "2005-12-05" @default.
• W1908457469 modified "2023-10-17" @default.
• W1908457469 title "Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1+AβPP mouse model of Alzheimer's disease" @default.
• W1908457469 cites W1481263059 @default.
• W1908457469 cites W1489410968 @default.
• W1908457469 cites W149130878 @default.
• W1908457469 cites W1497064282 @default.
• W1908457469 cites W1519363809 @default.
• W1908457469 cites W1662308449 @default.
• W1908457469 cites W1838909952 @default.
• W1908457469 cites W1896970469 @default.
• W1908457469 cites W1970696723 @default.
• W1908457469 cites W1976845082 @default.
• W1908457469 cites W1983789627 @default.
• W1908457469 cites W1995186464 @default.
• W1908457469 cites W1997625137 @default.
• W1908457469 cites W1998179320 @default.
• W1908457469 cites W1998849703 @default.
• W1908457469 cites W1999890389 @default.
• W1908457469 cites W2011029903 @default.
• W1908457469 cites W2014094971 @default.
• W1908457469 cites W2015163544 @default.
• W1908457469 cites W2015556811 @default.
• W1908457469 cites W2017197169 @default.
• W1908457469 cites W2017583361 @default.
• W1908457469 cites W2024141877 @default.
• W1908457469 cites W2024428227 @default.
• W1908457469 cites W2029115752 @default.
• W1908457469 cites W2042832760 @default.
• W1908457469 cites W2047210662 @default.
• W1908457469 cites W2049262684 @default.
• W1908457469 cites W2056693754 @default.
• W1908457469 cites W2062532849 @default.
• W1908457469 cites W2068412840 @default.
• W1908457469 cites W2069787626 @default.
• W1908457469 cites W2071514245 @default.
• W1908457469 cites W2077464099 @default.
• W1908457469 cites W2085205909 @default.
• W1908457469 cites W2106389606 @default.
• W1908457469 cites W2106791925 @default.
• W1908457469 cites W2106814023 @default.
• W1908457469 cites W2112078820 @default.
• W1908457469 cites W2113470143 @default.
• W1908457469 cites W2126950194 @default.
• W1908457469 cites W2129224791 @default.
• W1908457469 cites W2132083914 @default.
• W1908457469 cites W2133083344 @default.
• W1908457469 cites W2135011583 @default.
• W1908457469 cites W2155894885 @default.
• W1908457469 cites W2160337925 @default.
• W1908457469 cites W2160648492 @default.
• W1908457469 cites W2253907259 @default.
• W1908457469 doi "https://doi.org/10.3233/jad-2005-8302" @default.
• W1908457469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16340081" @default.
• W1908457469 hasPublicationYear "2005" @default.
• W1908457469 type Work @default.
• W1908457469 sameAs 1908457469 @default.
• W1908457469 citedByCount "24" @default.
• W1908457469 countsByYear W19084574692012 @default.
• W1908457469 countsByYear W19084574692013 @default.
• W1908457469 countsByYear W19084574692015 @default.
• W1908457469 countsByYear W19084574692016 @default.
• W1908457469 crossrefType "journal-article" @default.
• W1908457469 hasAuthorship W1908457469A5006563536 @default.
• W1908457469 hasAuthorship W1908457469A5010842155 @default.
• W1908457469 hasAuthorship W1908457469A5032386364 @default.
• W1908457469 hasAuthorship W1908457469A5051732343 @default.
• W1908457469 hasAuthorship W1908457469A5062603565 @default.
• W1908457469 hasAuthorship W1908457469A5077716269 @default.
• W1908457469 hasAuthorship W1908457469A5080895261 @default.
• W1908457469 hasAuthorship W1908457469A5089219708 @default.
• W1908457469 hasConcept C102230213 @default.
• W1908457469 hasConcept C104317684 @default.
• W1908457469 hasConcept C141035611 @default.
• W1908457469 hasConcept C142724271 @default.
• W1908457469 hasConcept C175344181 @default.
• W1908457469 hasConcept C2776151105 @default.
• W1908457469 hasConcept C2779134260 @default.
• W1908457469 hasConcept C46111723 @default.
• W1908457469 hasConcept C502032728 @default.
• W1908457469 hasConcept C55493867 @default.
• W1908457469 hasConcept C70721500 @default.
• W1908457469 hasConcept C71924100 @default.
• W1908457469 hasConcept C86803240 @default.
• W1908457469 hasConcept C95444343 @default.
• W1908457469 hasConceptScore W1908457469C102230213 @default.
• W1908457469 hasConceptScore W1908457469C104317684 @default.
• W1908457469 hasConceptScore W1908457469C141035611 @default.

• next