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• W1908676835 endingPage "1091" @default.
• W1908676835 startingPage "1086" @default.
• W1908676835 abstract "Current methods for measuring cerebral blood volume (CBV) in newborn infants are unsatisfactory. A new method is described in which the effect of a small change (5-10%) in arterial oxygen saturation (SaO2) on cerebral oxyhemoglobin [HbO2] and deoxyhemoglobin [Hb] concentration is observed by near-infrared (NIR) spectroscopy. Previous experiments in which the NIR absorption characteristics of HbO2 and Hb and the pathlength of NIR light through the brain were defined allowed changes in [HbO2] and [Hb] to be quantified from the Beer-Lambert law. It is shown here that CBV can then be derived from the expression CBV = (delta[HbO2] - delta[Hb])/(2. delta SaO2.H.R.), where H is the large vessel total hemoglobin concentration and R to the cerebral-to-large vessel hematocrit ratio. Observations on 12 newborn infants with normal brains, born at 25-40 wk of gestation and aged 10-240 h, gave a mean value for CBV of 2.22 +/- 0.40 (SD) ml/100 g, whereas mean CBV was significantly higher 3.00 +/- 1.04 ml/100 g in 10 infants with brain injury born at 24 to 42 wk of gestation and aged 4-168 h (P less than 0.05)." @default.
• W1908676835 created "2016-06-24" @default.
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• W1908676835 date "1990-03-01" @default.
• W1908676835 modified "2023-10-10" @default.
• W1908676835 title "Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy" @default.
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• W1908676835 doi "https://doi.org/10.1152/jappl.1990.68.3.1086" @default.
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