Matches in SemOpenAlex for { <https://semopenalex.org/work/W1908788336> ?p ?o ?g. }
- W1908788336 endingPage "6474" @default.
- W1908788336 startingPage "6467" @default.
- W1908788336 abstract "Adenoid cystic carcinoma (ACC) is one of the most common types of salivary gland malignancy in the head and neck, and its aggressive ability to invade and metastasize is an important reason for its poor survival rates. Our previous investigations confirmed that autophagy‑associated gene expression is closely associated with the occurrence and development of ACC. On this basis, the present study further investigated hypoxia‑induced autophagy and its role in tumor invasion. Cobalt chloride (CoCl2) was used to mimic hypoxia. The results of the present study indicated that autophagosome formation and upregulation of autophagy‑associated microtubule‑associated protein 1 light chain 3 and Beclin 1 were observed in ACC‑M cells in response to CoCl2. The hypoxia‑inducible factor 1α/B cell lymphoma 2/adenovirus E1B 19K‑interacting protein 3 signaling pathway was involved in hypoxia‑induced autophagy in ACC. Furthermore, inhibition of autophagy by chloroquine markedly attenuated the tumor invasion induced by mimetic hypoxia in ACC. These results suggested that hypoxia‑induced autophagy may serve as a potential target for the future treatment of ACC." @default.
- W1908788336 created "2016-06-24" @default.
- W1908788336 creator A5014020324 @default.
- W1908788336 creator A5016316795 @default.
- W1908788336 creator A5025154293 @default.
- W1908788336 creator A5066018914 @default.
- W1908788336 creator A5066778906 @default.
- W1908788336 creator A5087055223 @default.
- W1908788336 date "2015-08-26" @default.
- W1908788336 modified "2023-10-11" @default.
- W1908788336 title "Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway" @default.
- W1908788336 cites W1523693806 @default.
- W1908788336 cites W1856533655 @default.
- W1908788336 cites W1939123621 @default.
- W1908788336 cites W1963521777 @default.
- W1908788336 cites W1966148920 @default.
- W1908788336 cites W1972363481 @default.
- W1908788336 cites W1975801429 @default.
- W1908788336 cites W1976869962 @default.
- W1908788336 cites W1987038381 @default.
- W1908788336 cites W1995901075 @default.
- W1908788336 cites W2008946188 @default.
- W1908788336 cites W2036026634 @default.
- W1908788336 cites W2036222374 @default.
- W1908788336 cites W2038469506 @default.
- W1908788336 cites W2038592957 @default.
- W1908788336 cites W2052041444 @default.
- W1908788336 cites W2060385207 @default.
- W1908788336 cites W2063689445 @default.
- W1908788336 cites W2066708019 @default.
- W1908788336 cites W2067123623 @default.
- W1908788336 cites W2071293604 @default.
- W1908788336 cites W2072839085 @default.
- W1908788336 cites W2080505763 @default.
- W1908788336 cites W2082776359 @default.
- W1908788336 cites W2084379750 @default.
- W1908788336 cites W2085447305 @default.
- W1908788336 cites W2085586604 @default.
- W1908788336 cites W2086364834 @default.
- W1908788336 cites W2097170164 @default.
- W1908788336 cites W2114293452 @default.
- W1908788336 cites W2117649842 @default.
- W1908788336 cites W2140912399 @default.
- W1908788336 cites W2141528928 @default.
- W1908788336 cites W2149551965 @default.
- W1908788336 cites W2158535498 @default.
- W1908788336 cites W2160845673 @default.
- W1908788336 cites W2169110426 @default.
- W1908788336 doi "https://doi.org/10.3892/mmr.2015.4255" @default.
- W1908788336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4626194" @default.
- W1908788336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26323347" @default.
- W1908788336 hasPublicationYear "2015" @default.
- W1908788336 type Work @default.
- W1908788336 sameAs 1908788336 @default.
- W1908788336 citedByCount "64" @default.
- W1908788336 countsByYear W19087883362015 @default.
- W1908788336 countsByYear W19087883362016 @default.
- W1908788336 countsByYear W19087883362017 @default.
- W1908788336 countsByYear W19087883362018 @default.
- W1908788336 countsByYear W19087883362019 @default.
- W1908788336 countsByYear W19087883362020 @default.
- W1908788336 countsByYear W19087883362021 @default.
- W1908788336 countsByYear W19087883362022 @default.
- W1908788336 countsByYear W19087883362023 @default.
- W1908788336 crossrefType "journal-article" @default.
- W1908788336 hasAuthorship W1908788336A5014020324 @default.
- W1908788336 hasAuthorship W1908788336A5016316795 @default.
- W1908788336 hasAuthorship W1908788336A5025154293 @default.
- W1908788336 hasAuthorship W1908788336A5066018914 @default.
- W1908788336 hasAuthorship W1908788336A5066778906 @default.
- W1908788336 hasAuthorship W1908788336A5087055223 @default.
- W1908788336 hasBestOaLocation W19087883361 @default.
- W1908788336 hasConcept C104317684 @default.
- W1908788336 hasConcept C121608353 @default.
- W1908788336 hasConcept C127561419 @default.
- W1908788336 hasConcept C1491633281 @default.
- W1908788336 hasConcept C178790620 @default.
- W1908788336 hasConcept C185592680 @default.
- W1908788336 hasConcept C190283241 @default.
- W1908788336 hasConcept C203522944 @default.
- W1908788336 hasConcept C2776530083 @default.
- W1908788336 hasConcept C2776833033 @default.
- W1908788336 hasConcept C2777546739 @default.
- W1908788336 hasConcept C2779231225 @default.
- W1908788336 hasConcept C2781018059 @default.
- W1908788336 hasConcept C29537977 @default.
- W1908788336 hasConcept C502942594 @default.
- W1908788336 hasConcept C540031477 @default.
- W1908788336 hasConcept C54355233 @default.
- W1908788336 hasConcept C55493867 @default.
- W1908788336 hasConcept C7836513 @default.
- W1908788336 hasConcept C86803240 @default.
- W1908788336 hasConcept C95444343 @default.
- W1908788336 hasConceptScore W1908788336C104317684 @default.
- W1908788336 hasConceptScore W1908788336C121608353 @default.
- W1908788336 hasConceptScore W1908788336C127561419 @default.
- W1908788336 hasConceptScore W1908788336C1491633281 @default.
- W1908788336 hasConceptScore W1908788336C178790620 @default.