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• W1909111844 startingPage "233" @default.
• W1909111844 abstract "Age is known to affect prefrontal brain structure and executive functioning in healthy older adults, patients with neurodegenerative conditions and TBI. Yet, no studies appear to have systematically investigated the effect of age on cognitive performance in patients with focal lesions. We investigated the effect of age on the cognitive performance of a large sample of tumour and stroke patients with focal unilateral, frontal (n=68), or non-frontal lesions (n=45) and healthy controls (n=52). We retrospectively reviewed their cross sectional cognitive and imaging data. In our frontal patients, age significantly predicted the magnitude of their impairment on two executive tests (Raven's Advanced Progressive Matrices, RAPM and the Stroop test) but not on nominal (Graded Naming Test, GNT) or perceptual (Incomplete Letters) task. In our non-frontal patients, age did not predict the magnitude of their impairment on the RAPM and GNT. Furthermore, the exacerbated executive impairment observed in our frontal patients manifested itself from middle age. We found that only age consistently predicted the exacerbated executive impairment. Lesions to specific frontal areas, or an increase in global brain atrophy or white matter abnormalities were not associated with this impairment. Our results are in line with the notion that the frontal cortex plays a critical role in aging to counteract cognitive and neuronal decline. We suggest that the combined effect of aging and frontal lesions impairs the frontal cortical systems by causing its computational power to fall below the threshold needed to complete executive tasks successfully." @default.
• W1909111844 created "2016-06-24" @default.
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• W1909111844 date "2015-08-01" @default.
• W1909111844 modified "2023-10-13" @default.
• W1909111844 title "The effect of age on cognitive performance of frontal patients" @default.
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• W1909111844 doi "https://doi.org/10.1016/j.neuropsychologia.2015.06.011" @default.
• W1909111844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4542524" @default.
• W1909111844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26102190" @default.
• W1909111844 hasPublicationYear "2015" @default.
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