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• W1909135811 endingPage "G1176" @default.
• W1909135811 startingPage "G1169" @default.
• W1909135811 abstract "We previously reported that primary cultures of guinea pig gastric pit cells expressed all of the phagocyte NADPH oxidase components (gp91-, p22-, p67-, p47-, and p40-phox) and could spontaneously release superoxide anion (O(2)(-)). We demonstrate here that pit cells express a nonphagocyte-specific gp91-phox homolog (Mox1) but not gp91-phox. Inclusion of catalase significantly inhibited [(3)H]thymidine uptake during the initial 2 days of culture. Pit cells, matured on day 2, slowly underwent spontaneous apoptosis. Scavenging O(2)(-) and related oxidants by superoxide dismutase plus catalase or N-acetyl cysteine (NAC) and inhibiting Mox1 oxidase by diphenylene iodonium activated caspase 3-like proteases and markedly enhanced chromatin condensation and DNA fragmentation. This accelerated apoptosis was completely blocked by a caspase inhibitor, z-Val-Ala-Asp-CH(2)F. Mox1-derived reactive oxygen intermediates constitutively activated nuclear factor-kappaB, and inhibition of this activity by nuclear factor-kappaB decoy oligodeoxynucleotide accelerated their spontaneous apoptosis. These results suggest that O(2)(-) produced by the pit cell Mox1 oxidase may play a crucial role in the regulation of their spontaneous apoptosis as well as cell proliferation." @default.
• W1909135811 created "2016-06-24" @default.
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• W1909135811 date "2000-12-01" @default.
• W1909135811 modified "2023-09-24" @default.
• W1909135811 title "Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1" @default.
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• W1909135811 doi "https://doi.org/10.1152/ajpgi.2000.279.6.g1169" @default.
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