Matches in SemOpenAlex for { <https://semopenalex.org/work/W1909440441> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1909440441 endingPage "284" @default.
- W1909440441 startingPage "277" @default.
- W1909440441 abstract "Purpose: Aberrant DNA methylation of tumor suppressor genes has been accepted as a common feature and early event in human cancer. The aim of this study was to analyze the methylation profiles of 50 well established methylation-associated genes in relation to various clinico-pathological features in breast cancer. Methods: The methylation status of 50 genes were determined in two breast cancer cell lines, MCF7 and MDAMB231, using HpaII-MspI-PCR. 8 genes (APC, CALCA, CDH13, MTHFR, S100A2, H19, EDNRB and MUC2) were found to be methylated in at least 1 cell line. The methylation of all 8 genes was observed in tumor tissues, but with different methylation frequencies. Results: The methylation frequencies of five genes in breast cancer were as follows: MTHFR (41.9%), APC (51.6%), EDNRB (77.4%), CALCA (80.6%), S100A2 (87.1%), CDH13 (93.5%), H19 (93.5%) and MUC2 (96.8%). The results indicate that a panel of these 8 genes would be useful in the detection of breast cancer. The prognostic significance of DNA methylation in this breast cancer series, the conventional markers of LN status (P=0.05), histologic grade (P=0.007) and P53 gene status (P=0.049) showed significant prognostic value. Conclusion: The methylation of APC, MTHFR, CALCA, CDH13, H19, MUC2, EDNRB and S00A2 would be useful in the detection of breast cancer. Detection of these abnormalities may be useful in the risk assessment and early detection of breast cancer." @default.
- W1909440441 created "2016-06-24" @default.
- W1909440441 creator A5001645103 @default.
- W1909440441 creator A5006011848 @default.
- W1909440441 creator A5035935731 @default.
- W1909440441 creator A5040630572 @default.
- W1909440441 creator A5076887902 @default.
- W1909440441 date "2007-10-01" @default.
- W1909440441 modified "2023-09-24" @default.
- W1909440441 title "Promoter Methylation Profiles and Its Association with Clinicopathological Features in Breast Cancer" @default.
- W1909440441 cites W1905879952 @default.
- W1909440441 hasPublicationYear "2007" @default.
- W1909440441 type Work @default.
- W1909440441 sameAs 1909440441 @default.
- W1909440441 citedByCount "0" @default.
- W1909440441 crossrefType "journal-article" @default.
- W1909440441 hasAuthorship W1909440441A5001645103 @default.
- W1909440441 hasAuthorship W1909440441A5006011848 @default.
- W1909440441 hasAuthorship W1909440441A5035935731 @default.
- W1909440441 hasAuthorship W1909440441A5040630572 @default.
- W1909440441 hasAuthorship W1909440441A5076887902 @default.
- W1909440441 hasConcept C104317684 @default.
- W1909440441 hasConcept C121608353 @default.
- W1909440441 hasConcept C126322002 @default.
- W1909440441 hasConcept C135763542 @default.
- W1909440441 hasConcept C143998085 @default.
- W1909440441 hasConcept C150194340 @default.
- W1909440441 hasConcept C190727270 @default.
- W1909440441 hasConcept C2777162945 @default.
- W1909440441 hasConcept C33288867 @default.
- W1909440441 hasConcept C43563269 @default.
- W1909440441 hasConcept C502942594 @default.
- W1909440441 hasConcept C530470458 @default.
- W1909440441 hasConcept C54355233 @default.
- W1909440441 hasConcept C555283112 @default.
- W1909440441 hasConcept C71924100 @default.
- W1909440441 hasConcept C86803240 @default.
- W1909440441 hasConceptScore W1909440441C104317684 @default.
- W1909440441 hasConceptScore W1909440441C121608353 @default.
- W1909440441 hasConceptScore W1909440441C126322002 @default.
- W1909440441 hasConceptScore W1909440441C135763542 @default.
- W1909440441 hasConceptScore W1909440441C143998085 @default.
- W1909440441 hasConceptScore W1909440441C150194340 @default.
- W1909440441 hasConceptScore W1909440441C190727270 @default.
- W1909440441 hasConceptScore W1909440441C2777162945 @default.
- W1909440441 hasConceptScore W1909440441C33288867 @default.
- W1909440441 hasConceptScore W1909440441C43563269 @default.
- W1909440441 hasConceptScore W1909440441C502942594 @default.
- W1909440441 hasConceptScore W1909440441C530470458 @default.
- W1909440441 hasConceptScore W1909440441C54355233 @default.
- W1909440441 hasConceptScore W1909440441C555283112 @default.
- W1909440441 hasConceptScore W1909440441C71924100 @default.
- W1909440441 hasConceptScore W1909440441C86803240 @default.
- W1909440441 hasIssue "4" @default.
- W1909440441 hasLocation W19094404411 @default.
- W1909440441 hasOpenAccess W1909440441 @default.
- W1909440441 hasPrimaryLocation W19094404411 @default.
- W1909440441 hasRelatedWork W1597681369 @default.
- W1909440441 hasRelatedWork W1791425304 @default.
- W1909440441 hasRelatedWork W1983339712 @default.
- W1909440441 hasRelatedWork W2002274937 @default.
- W1909440441 hasRelatedWork W2007199559 @default.
- W1909440441 hasRelatedWork W2012699762 @default.
- W1909440441 hasRelatedWork W2088716532 @default.
- W1909440441 hasRelatedWork W2127855948 @default.
- W1909440441 hasRelatedWork W2168364914 @default.
- W1909440441 hasRelatedWork W2253155934 @default.
- W1909440441 hasRelatedWork W2276102892 @default.
- W1909440441 hasRelatedWork W2301006163 @default.
- W1909440441 hasRelatedWork W2317782839 @default.
- W1909440441 hasRelatedWork W2360781136 @default.
- W1909440441 hasRelatedWork W2734721597 @default.
- W1909440441 hasRelatedWork W2783109906 @default.
- W1909440441 hasRelatedWork W2995534950 @default.
- W1909440441 hasRelatedWork W3030366493 @default.
- W1909440441 hasRelatedWork W3185358939 @default.
- W1909440441 hasRelatedWork W2252576177 @default.
- W1909440441 hasVolume "73" @default.
- W1909440441 isParatext "false" @default.
- W1909440441 isRetracted "false" @default.
- W1909440441 magId "1909440441" @default.
- W1909440441 workType "article" @default.