FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1909552007> ?p ?o ?g. }

• W1909552007 endingPage "10" @default.
• W1909552007 startingPage "403" @default.
• W1909552007 abstract "Angiotensin 1-7 (Ang 1-7) has been reported to induce relaxation which is partially blocked by a kinin receptor antagonist. We investigated the relationship between kinins and angiotensin peptides with use of preconstricted isolated pig coronary arteries. Ang 1-7 alone (up to 10(-5) M) had no relaxant effect. Bradykinin (BK) (10(-10)-10(-7) M) induced transient relaxation, returning to basal tone, although BK remained in the bath. In these BK-stimulated rings, Ang 1-7 but not BK (both 5 x 10(-6) M) again relaxed the rings by approximately 50%. This relaxation was blocked by a BK B2 antagonist, a kininase, and a nitric oxide synthase inhibitor. Ang 1-7 inhibited purified angiotensin-converting enzyme (ACE) by 30 +/- 3.5% (n = 4) at 10(-6) M. However, in BK-pretreated rings, the ACE inhibitor ramiprilat did not induce relaxation, nor did it affect the relaxant response to Ang 1-7, which suggests that the effect of Ang 1-7 was not caused by ACE inhibition. Ang 1-7-induced vasodilation was reduced by 69.9 +/- 6.2% by an AT2 receptor blocker, PD-123319, and 29.3 +/- 7.3% by an AT1 antagonist, losartan. Neither the nonselective AT1/AT2 receptor antagonist sarthran nor saralasin inhibited the response to Ang 1-7. Ang II did not elicit relaxation either alone or in the presence of losartan, which suggests that activation of AT2 receptors does not cause relaxation. Thus, in the presence of bradykinin, Ang 1-7 relaxes pig coronary arteries via a PD-123319-sensitive mechanism involving nitric oxide, kinins and the BK B2 receptor. The kallikrein-kinin and renin-angiotensin systems may be linked through the interaction of Ang 1-7 and BK." @default.
• W1909552007 created "2016-06-24" @default.
• W1909552007 creator A5011043569 @default.
• W1909552007 creator A5045934111 @default.
• W1909552007 creator A5075458937 @default.
• W1909552007 date "1998-07-01" @default.
• W1909552007 modified "2023-09-23" @default.
• W1909552007 title "Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery." @default.
• W1909552007 cites W1504118827 @default.
• W1909552007 cites W1536093676 @default.
• W1909552007 cites W1575812822 @default.
• W1909552007 cites W1832708658 @default.
• W1909552007 cites W1856522064 @default.
• W1909552007 cites W1968425665 @default.
• W1909552007 cites W1970068637 @default.
• W1909552007 cites W1971097984 @default.
• W1909552007 cites W1975014009 @default.
• W1909552007 cites W1975291885 @default.
• W1909552007 cites W1986284688 @default.
• W1909552007 cites W1988453846 @default.
• W1909552007 cites W1990632689 @default.
• W1909552007 cites W1996530741 @default.
• W1909552007 cites W2002717483 @default.
• W1909552007 cites W2010031713 @default.
• W1909552007 cites W2014176508 @default.
• W1909552007 cites W2024416570 @default.
• W1909552007 cites W2027504703 @default.
• W1909552007 cites W2030806442 @default.
• W1909552007 cites W2034963012 @default.
• W1909552007 cites W2041718175 @default.
• W1909552007 cites W2042789374 @default.
• W1909552007 cites W2055571465 @default.
• W1909552007 cites W2061742938 @default.
• W1909552007 cites W2071174074 @default.
• W1909552007 cites W2075350698 @default.
• W1909552007 cites W2079577579 @default.
• W1909552007 cites W2079891784 @default.
• W1909552007 cites W2080248232 @default.
• W1909552007 cites W2083030828 @default.
• W1909552007 cites W2103115053 @default.
• W1909552007 cites W2104598696 @default.
• W1909552007 cites W2108297320 @default.
• W1909552007 cites W2115466950 @default.
• W1909552007 cites W2120590566 @default.
• W1909552007 cites W2127293529 @default.
• W1909552007 cites W2131033837 @default.
• W1909552007 cites W2133134128 @default.
• W1909552007 cites W2134593344 @default.
• W1909552007 cites W2147355520 @default.
• W1909552007 cites W2149860264 @default.
• W1909552007 cites W2151166210 @default.
• W1909552007 cites W2152895491 @default.
• W1909552007 cites W2220071166 @default.
• W1909552007 cites W2283019668 @default.
• W1909552007 cites W2287532303 @default.
• W1909552007 cites W2299203933 @default.
• W1909552007 cites W2320588875 @default.
• W1909552007 cites W2324804902 @default.
• W1909552007 cites W2345841378 @default.
• W1909552007 cites W2410158672 @default.
• W1909552007 cites W1820918747 @default.
• W1909552007 cites W2618500906 @default.
• W1909552007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9655885" @default.
• W1909552007 hasPublicationYear "1998" @default.
• W1909552007 type Work @default.
• W1909552007 sameAs 1909552007 @default.
• W1909552007 citedByCount "25" @default.
• W1909552007 countsByYear W19095520072012 @default.
• W1909552007 countsByYear W19095520072013 @default.
• W1909552007 countsByYear W19095520072014 @default.
• W1909552007 countsByYear W19095520072015 @default.
• W1909552007 countsByYear W19095520072016 @default.
• W1909552007 countsByYear W19095520072018 @default.
• W1909552007 countsByYear W19095520072020 @default.
• W1909552007 countsByYear W19095520072021 @default.
• W1909552007 crossrefType "journal-article" @default.
• W1909552007 hasAuthorship W1909552007A5011043569 @default.
• W1909552007 hasAuthorship W1909552007A5045934111 @default.
• W1909552007 hasAuthorship W1909552007A5075458937 @default.
• W1909552007 hasConcept C120770815 @default.
• W1909552007 hasConcept C123915805 @default.
• W1909552007 hasConcept C126322002 @default.
• W1909552007 hasConcept C134018914 @default.
• W1909552007 hasConcept C170493617 @default.
• W1909552007 hasConcept C185592680 @default.
• W1909552007 hasConcept C27016395 @default.
• W1909552007 hasConcept C2776246183 @default.
• W1909552007 hasConcept C2776823063 @default.
• W1909552007 hasConcept C2776885963 @default.
• W1909552007 hasConcept C2778122271 @default.
• W1909552007 hasConcept C2779591629 @default.
• W1909552007 hasConcept C2779611605 @default.
• W1909552007 hasConcept C2780288358 @default.
• W1909552007 hasConcept C2908929049 @default.
• W1909552007 hasConcept C71924100 @default.
• W1909552007 hasConcept C84393581 @default.
• W1909552007 hasConceptScore W1909552007C120770815 @default.
• W1909552007 hasConceptScore W1909552007C123915805 @default.

• next