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• W1909553386 endingPage "471" @default.
• W1909553386 startingPage "457" @default.
• W1909553386 abstract "Drug delivery across skin offers advantages over conventional modes of administration. It avoids gastrointestinal degradation and the hepatic first-pass effect, has potential for controlled and sustained delivery, is user-friendly and therefore improves patient compliance (1–2). However, because the skin’s outer layer, the stratum corneum, is an extremely effective barrier, transdermal transport of most drugs is very slow, exhibits lag times of hours and steadystate rates that are often subtherapeutic. Chemical and physical approaches to increasing transdermal transport have been explored. Recently, the intermittent application of short (e.g., milliseconds), high-voltage (e.g., 100 V across skin) pulses has been shown to increase transport across skin by several orders of magnitude on a time scale of minutes, probably by a mechanism involving electroporation (3–6)." @default.
• W1909553386 created "2016-06-24" @default.
• W1909553386 creator A5001987906 @default.
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• W1909553386 date "2003-11-14" @default.
• W1909553386 modified "2023-10-18" @default.
• W1909553386 title "Transdermal Drug Delivery by Skin Electroporation in the Rat" @default.
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• W1909553386 doi "https://doi.org/10.1385/1-59259-080-2:457" @default.
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