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- W1909716069 abstract "Abstract The best-characterized insulator in Drosophila melanogaster is the Su(Hw)-binding region contained within the gypsy retrotransposon. In the y2 mutant, Su(Hw) protein partially inhibits yellow transcription by blocking the function of transcriptional enhancers located distally from the yellow promoter with respect to gypsy. Previously we have shown that yellow enhancers can overcome inhibition by a downstream insulator in the yrh1 allele, when a second gypsy element is located upstream of the enhancers. To understand how two insulators neutralize each other, we isolated various deletions that terminate in the regulatory region of the yrh1 allele. To generate these alleles we used DNA elongation by gene conversion of the truncated chromosomes at the end of the yellow regulatory region. We found that gypsy insulator can function at the end of the truncated chromosome. Addition of the gypsy insulator upstream of the yellow enhancers overcomes the enhancer-blocking activity of the gypsy insulator inserted between the yellow enhancers and promoter. These results suggest that the gypsy insulators do not form separate transcriptional domains that delimit the interactions between enhancers and promoters." @default.
- W1909716069 created "2016-06-24" @default.
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- W1909716069 creator A5057581244 @default.
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- W1909716069 date "2002-04-01" @default.
- W1909716069 modified "2023-09-27" @default.
- W1909716069 title "The gypsy Insulators Flanking yellow Enhancers Do Not Form a Separate Transcriptional Domain in Drosophila melanogaster: The Enhancers Can Activate an Isolated yellow Promoter" @default.
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- W1909716069 doi "https://doi.org/10.1093/genetics/160.4.1549" @default.
- W1909716069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462042" @default.
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- W1909716069 hasPublicationYear "2002" @default.
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