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- W1909778924 abstract "Abstract The function and mechanism of macropinocytosis in cells outside of the immune system remain poorly understood. We used a neuroblastoma cell line, Neuro‐2a, to study macropinocytosis in neuronal cells. We found that phorbol 12‐myristate 13‐acetate (PMA) and insulin‐like growth factor 1 (IGF‐1) induced two distinct types of macropinocytosis in the Neuro‐2a cells. IGF‐1‐induced macropinocytosis occurs mostly around the cell bodies and requires phosphoinositide 3‐kinase (PI3K), while PMA‐induced macropinocytosis occurs predominantly in the neurites and is independent of PI3K activity. Both types of macropinocytosis were inhibited by a specific inhibitor of nonmuscle myosin II, blebbistatin. siRNA knockdown of nonmuscle myosin II isoforms, ‐IIA and ‐IIB, resulted in opposite effects on macropinocytosis induced by PMA or IGF. Myosin IIA knockdown significantly increased, whereas myosin IIB knockdown significantly decreased, macropinocytosis with correlating changes in membrane ruffle formation. © 2009 Wiley‐Liss, Inc." @default.
- W1909778924 created "2016-06-24" @default.
- W1909778924 creator A5013339403 @default.
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- W1909778924 date "2010-01-01" @default.
- W1909778924 modified "2023-10-18" @default.
- W1909778924 title "Myosin IIB isoform plays an essential role in the formation of two distinct types of macropinosomes" @default.
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- W1909778924 doi "https://doi.org/10.1002/cm.20419" @default.
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