Matches in SemOpenAlex for { <https://semopenalex.org/work/W1909857029> ?p ?o ?g. }
- W1909857029 endingPage "367" @default.
- W1909857029 startingPage "357" @default.
- W1909857029 abstract "The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA) and substantia nigra. These inputs appear to provide a modulatory signal that influences hippocampus-dependent behaviors. Enhancements in working memory performance have been previously reported following acute smoking/nicotine exposure. However, the underlying mechanism remains unclear. This study investigated the effects of nicotine on spatial working memory (SWM) and the mechanisms involved. Delayed alternation T-maze task was used to assess SWM. In situ and gel gelatin zymography were used to detect matrix metalloproteinase-9 (MMP-9) in SWM. Systemic or local (intra-VTA) administration of nicotine significantly improves SWM, which was accompanied by increased MMP-9 activity in dorsal hippocampus (dHPC). Intra-dHPC administration of MMP inhibitor FN-439 abolished the memory enhancement induced by intra-VTA nicotine infusion. FN-439 had no effect on locomotor behavior. Our data suggest that intra-VTA nicotine infusion activates MMP-9 in dHPC to improve SWM in rats." @default.
- W1909857029 created "2016-06-24" @default.
- W1909857029 creator A5013666844 @default.
- W1909857029 creator A5022500520 @default.
- W1909857029 creator A5032459548 @default.
- W1909857029 creator A5034618391 @default.
- W1909857029 creator A5035219298 @default.
- W1909857029 creator A5041296596 @default.
- W1909857029 creator A5046593132 @default.
- W1909857029 creator A5074628946 @default.
- W1909857029 creator A5091575452 @default.
- W1909857029 date "2015-09-02" @default.
- W1909857029 modified "2023-10-06" @default.
- W1909857029 title "Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra‐<scp>VTA</scp> nicotine infusion in rats" @default.
- W1909857029 cites W1125689587 @default.
- W1909857029 cites W1540199296 @default.
- W1909857029 cites W1737750271 @default.
- W1909857029 cites W1911664005 @default.
- W1909857029 cites W1964667843 @default.
- W1909857029 cites W1966416634 @default.
- W1909857029 cites W1968939747 @default.
- W1909857029 cites W1971993069 @default.
- W1909857029 cites W1972975985 @default.
- W1909857029 cites W1983985508 @default.
- W1909857029 cites W1985002194 @default.
- W1909857029 cites W1988552996 @default.
- W1909857029 cites W1990122650 @default.
- W1909857029 cites W1992431665 @default.
- W1909857029 cites W1998067671 @default.
- W1909857029 cites W2016447003 @default.
- W1909857029 cites W2020811579 @default.
- W1909857029 cites W2023076733 @default.
- W1909857029 cites W2025008532 @default.
- W1909857029 cites W2031534534 @default.
- W1909857029 cites W2034648042 @default.
- W1909857029 cites W2037476043 @default.
- W1909857029 cites W2040922836 @default.
- W1909857029 cites W2045343782 @default.
- W1909857029 cites W2046293966 @default.
- W1909857029 cites W2047917857 @default.
- W1909857029 cites W2050633111 @default.
- W1909857029 cites W2066785847 @default.
- W1909857029 cites W2068587092 @default.
- W1909857029 cites W2073259535 @default.
- W1909857029 cites W2073658290 @default.
- W1909857029 cites W2075604058 @default.
- W1909857029 cites W2079311820 @default.
- W1909857029 cites W2081773290 @default.
- W1909857029 cites W2087545154 @default.
- W1909857029 cites W2091746155 @default.
- W1909857029 cites W2101382722 @default.
- W1909857029 cites W2104866762 @default.
- W1909857029 cites W2105233285 @default.
- W1909857029 cites W2106085507 @default.
- W1909857029 cites W2107137914 @default.
- W1909857029 cites W2117308838 @default.
- W1909857029 cites W2119478343 @default.
- W1909857029 cites W2119591418 @default.
- W1909857029 cites W2120066727 @default.
- W1909857029 cites W2120895782 @default.
- W1909857029 cites W2121007598 @default.
- W1909857029 cites W2121948831 @default.
- W1909857029 cites W2122921281 @default.
- W1909857029 cites W2125051557 @default.
- W1909857029 cites W2132592261 @default.
- W1909857029 cites W2133956528 @default.
- W1909857029 cites W2139155720 @default.
- W1909857029 cites W2139478464 @default.
- W1909857029 cites W2153821084 @default.
- W1909857029 cites W2155569983 @default.
- W1909857029 cites W2256143 @default.
- W1909857029 doi "https://doi.org/10.1111/jnc.13283" @default.
- W1909857029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26263395" @default.
- W1909857029 hasPublicationYear "2015" @default.
- W1909857029 type Work @default.
- W1909857029 sameAs 1909857029 @default.
- W1909857029 citedByCount "13" @default.
- W1909857029 countsByYear W19098570292016 @default.
- W1909857029 countsByYear W19098570292017 @default.
- W1909857029 countsByYear W19098570292018 @default.
- W1909857029 countsByYear W19098570292019 @default.
- W1909857029 countsByYear W19098570292020 @default.
- W1909857029 countsByYear W19098570292021 @default.
- W1909857029 countsByYear W19098570292022 @default.
- W1909857029 countsByYear W19098570292023 @default.
- W1909857029 crossrefType "journal-article" @default.
- W1909857029 hasAuthorship W1909857029A5013666844 @default.
- W1909857029 hasAuthorship W1909857029A5022500520 @default.
- W1909857029 hasAuthorship W1909857029A5032459548 @default.
- W1909857029 hasAuthorship W1909857029A5034618391 @default.
- W1909857029 hasAuthorship W1909857029A5035219298 @default.
- W1909857029 hasAuthorship W1909857029A5041296596 @default.
- W1909857029 hasAuthorship W1909857029A5046593132 @default.
- W1909857029 hasAuthorship W1909857029A5074628946 @default.
- W1909857029 hasAuthorship W1909857029A5091575452 @default.
- W1909857029 hasBestOaLocation W19098570291 @default.
- W1909857029 hasConcept C137183658 @default.
- W1909857029 hasConcept C15744967 @default.