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- W1909876475 endingPage "103" @default.
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- W1909876475 abstract "PurposeDuring recent years, the interaction of cell surface molecule, extracellular matrix proteins, and cytoskeletal elements has been a topic for research for the purpose of understanding the mechanisms of pathologic conditions. This study aims to evaluate the expression of CD44, as a cell surface adhesion molecule; fibronectin (FN), as an extracellular and a cell surface protein; vinculin and actin/α-smooth muscle actin (α-SMA), as cytoskeletal elements; and the interactions of these proteins in the microenvironment of proliferative vitreoretinopathy (PVR). MethodsThis experimental study was designed by the intravitreal Dispase model in rabbits and proteins' expression were evaluated via immunohistochemical staining. ResultsAs a cell surface protein, CD44 expression was determined in only four eyes focally and weakly, but in a small number of cells. Among the cytoskeletal proteins, vinculin expression was the most extensive and the strongest in intensity in epi- and subretinal membranes. Alpha-SMA expression was mostly present within small foci of cells. Fibronectin expression was determined in some of the eyes only faintly. ConclusionsVinculin seems to be involved in PVR pathogenesis. Variability in co-distribution of the expression of vinculin, FN, and α-SMA reflects the dynamic interactions evolving between cell and extracellular matrix during the epi- and subretinal membrane formations. The results of this study were determined not to be in support of the assumption that CD44 has a functional role in the pathogenesis of PVR. (Eur J Ophthalmol 2007; 17: 89–103)" @default.
- W1909876475 created "2016-06-24" @default.
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- W1909876475 creator A5080254693 @default.
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- W1909876475 date "2007-01-01" @default.
- W1909876475 modified "2023-09-25" @default.
- W1909876475 title "Expression of Proteins Associated with Cell-Matrix Adhesion in Proliferative Vitreoretinopathy Designed by Dispase Model" @default.
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- W1909876475 doi "https://doi.org/10.1177/112067210701700113" @default.
- W1909876475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17294388" @default.
- W1909876475 hasPublicationYear "2007" @default.
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