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- W191002938 abstract "In order to study morphological (MRI) peculiarities of corpus callosum (CC), hippocampus, III and lateral ventricles and their temporal horns in the patients with schizophrenia and their unaffected 1st degree relatives 35 subjects were investigated: 12 patients, 15 parents and siblings and 8 controls. 3 mm coronal T1-weighed 3D magnetic resonance images acquired on 0,5 Tesla magnet Tomikon 550, Bruker (Germany). The initial MR pulse sequence SP GEFI 3D was modified during our research. High resolution MR-images and images at FLAIR mode was acquired. Morphometric analysis included the assessment of parameters of CC shape, displacement (PSD CC), area in midsagittal plan and tissue contrast index, hippocampal volumes, III and lateral ventricles and their temporal horns. The findings showed the tendency to decreasing of total hippocampal volumes, volume of the left hippocampus and to increasing of the volumes of III ventricle, lateral ventricles and their temporal horns (with prevalence of left-side abnormalities) in the patients with schizophrenia and their relatives (the most pronounced in patients) as compared with controls. There were no differences between the studied groups by the CC area. CC tissue contrast index was increased in patients and relatives (tendency). Alteration in CC shape and its vertical displacement as well as increased index of its tissue contrast (tendency) were demonstrated in patients and their relatives. The established tendencies to deviations of PSD CC suppose complex nature of ventriculomegalia in schizophrenia which relates both with predisposing factors (primary hydrocephalia) and atrophic process (presumably). Significant correlations of some PSD SS with the volumes of lateral ventricles (with right-side accent) and CC area in patients and PSD CC with the volumes of lateral ventricles in relatives were demonstrated. Relationships between the height of the inferior CC contour and global negative symptoms score (the level of significance) and between the volume of left hippocampus, total hippocampal volume and illness duration (tendency) were established. The results indicate the role of left temporal lobe structures in pathogenesis of schizophrenia and support the hypothesis about the role of pathology of genes controlling brain asymmetry for the disease expression." @default.
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- W191002938 date "2005-01-01" @default.
- W191002938 modified "2023-09-24" @default.
- W191002938 title "Структурные особенности мозга у больных шизофренией и их родственников i степени родства по данным морфометрического анализа МР-изображений мозга" @default.
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