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- W191009710 abstract "The off-label use of topical tacrolimus (Protopic) for inflammatory external eye diseases is gaining popularity. However, there are no reports on the safety profile of this new treatment option.We treated six patients with different inflammatory eye diseases with topical tacrolimus (Protopic 0.03 %) as off-label use in addition to the conventional anti-inflammatory treatment. Patients were interviewed for side effects and serum drug concentrations were measured under steady state conditions one hour after topical application of tacrolimus ointment.Two patients reported a slight burning sensation immediately after application, in one patient we found a slight worsening of the dry eye problems. No patient abandoned the treatment due to side effects. Serum drug concentrations remained below the analytical threshold in all cases (< 1.5 ng/ml).Tacrolimus for the topical treatment of anterior segment inflammatory eye diseases is well tolerated without detectable systemic drug resorption." @default.
- W191009710 created "2016-06-24" @default.
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- W191009710 date "2009-04-01" @default.
- W191009710 modified "2023-10-17" @default.
- W191009710 title "Sicherheit der Behandlung entzündlicher Vorderabschnittserkrankungen mit Tacrolimus-Salbe" @default.
- W191009710 doi "https://doi.org/10.1055/s-0028-1109328" @default.
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