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• W1910121196 startingPage "2889" @default.
• W1910121196 abstract "Abstract CD4 T cell help for B cells is critical for effective Ab responses. Although many of the molecules involved in helper functions of naive CD4 T cells have been characterized, much less is known about the helper capabilities of memory CD4 T cells, an important consideration for the design of vaccines that aim to prime protective memory CD4 T cells. In this study, we demonstrate that memory CD4 T cells enable B cells to expand more rapidly and class switch earlier than do primary responding CD4 T cells. This accelerated response does not require large numbers of memory cells, and similar numbers of primary responding cells provide less effective help than do memory cells. However, only memory CD4 T cells that express the B cell follicle homing molecule, CXCR5, are able to accelerate the response, suggesting that the rapidity of the Ab response depends on the ability of CD4 memory T cells to migrate quickly toward B cells." @default.
• W1910121196 created "2016-06-24" @default.
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• W1910121196 date "2011-03-01" @default.
• W1910121196 modified "2023-10-12" @default.
• W1910121196 title "Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells" @default.
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• W1910121196 doi "https://doi.org/10.4049/jimmunol.1002955" @default.
• W1910121196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3069687" @default.
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