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- W191013450 abstract "In his seminal bookBiochemical Systems Analysis: A Study of Function and Design in Molecular Biology, Savageau (1976) proposed an agenda toward a true understanding of complex networks in biology. In addition to developing mathematical models of specific phenomena, he suggested that more general and far-reaching insight could be gained from studying the generic designs of systems, such as mechanisms of feedback inhibition by end product, which were showing up in nature time and again. In an editorial forThe New BiologistSavageau (1991) illustrated the rationale for investigating designs with an instructive demonstration of the different levels of understanding that can be obtained with standard experimentation. He compared the quest for biological insight with different types of analyses of a television set. At the lowest level of understanding, the features of the TV set are simply described in terms of color, size, and shape. Thisdescription can extend to internal parts like the picture tube and is easily made quantitative. Clearly, science by description parallels the early beginnings of biology, where plants and animals were qualitatively, and later quantitatively, described and classified. Savageau identified as the next higher level theisolation and analysis of components. Each interesting-looking component may be analyzed in an electronics lab, and if it consists of a number of parts itself, one could disassemble the components and study each part. This strategy is calledreductionism and has been the dominant paradigm of biology in the twentieth century. In some sense, the completion of the human and other genome projects is the Holy Grail of this approach, because the genome is considered the blue print that implicitly contains all information needed for the functioning of an organism in its environment." @default.
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- W191013450 date "2004-01-01" @default.
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- W191013450 title "Design and Operation: Keys to Understanding Biological Systems" @default.
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