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- W1910201191 abstract "Background: Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias and carries a prognosis worse than many cancers. However, the pathogenesis of this disease remains incompletely understood.Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) is a 130 kDa glycoprotein that has been implicated in pulmonary fibrosis in a strain of knockout mice. We assess the prevalence of the PECAM-1 single gene polymorphisms and the serum concentration of PECAM-1 in IPF patients versus controls.Methods: Samples of full blood were collected from 37 patients with IPF and 41 controls. DNA was extracted from whole blood using QIAmp DNA Blood Midi Kit (Qiagen, Valencia, CA). PCR was performed using primers specific to exon 3, exon 8 and exon 12 of the PECAM-1 gene. Purified PCR products were sent to Eurofins MWG Operon for sequencing. The serum concentration of soluble PECAM-1 was assessed using ELISA.Results and discussion: No significant difference was observed in the prevalence of single gene polymorphisms in exon 3, 8 or 12 of the PECAM-1 gene. The serum PECAM-1 concentration was significantly higher in the IPF group versus controls (106.177ng/ml vs 84.327ng/ml respectively, p=0.0398) with elevated sPECAM-1 concentrations associated with better lung function (p=0.038).Conclusion: No significant difference in the prevalence of single gene polymorphisms in the PECAM-1 gene was observed between IPF and control groups. Serum PECAM-1 concentration was elevated in IPF patients versus controls however it is not possible to conclude whether this is important in the pathogenesis of the disease or a secondary event resulting from cell injury and aberrant tissue repair." @default.
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- W1910201191 date "2011-09-01" @default.
- W1910201191 modified "2023-09-22" @default.
- W1910201191 title "PECAM-1 single nucleotide polymorphisms and idiopathic pulmonary fibrosis" @default.
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