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- W1910276010 abstract "Vitamin D deficiency is a global health problem that has various adverse consequences. Vitamin D is mainly synthesized in the skin by sunlight (UV light) irradiation; therefore, vitamin D status is influenced by geographic locations, seasonal changes, and skin pigmentations. The kidney is involved in the biosynthesis of 1,25-dihydroxyvitamin D and the reuptake of filtered 25-hydroxyvitamin D from the proximal tubules, thus, vitamin D deficiency is highly prevalent in patients with kidney disease who have renal insufficiency. There is a growing body of epidemiological and clinical evidence in the literature that links vitamin D deficiency to cardiovascular disease. The discovery of the vitamin D hormone functioning as an endocrine inhibitor of the renin-angiotensin system provides an explanation for this association. This review will discuss the mechanism underlying the connection between vitamin D and cardiovascular disease and its physiological and therapeutic implications." @default.
- W1910276010 created "2016-06-24" @default.
- W1910276010 creator A5089137150 @default.
- W1910276010 date "2011-08-01" @default.
- W1910276010 modified "2023-09-27" @default.
- W1910276010 title "Molecular Mechanism of Vitamin D in the Cardiovascular System" @default.
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- W1910276010 doi "https://doi.org/10.2310/jim.0b013e31820ee448" @default.
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