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- W1910365967 abstract "The mapping of around 100 single nucleotide polymorphism (SNP) susceptibility variants for prostate cancer represents a remarkable technological achievement driven by large multicentre collaborations and the lower cost of genomic technologies. The high degree of statistical certainty for each SNP locus in duplicate or even triplicate experiments provides a series of waypoints defining a genetic landscape that accounts for an estimated 33% of familial risk. A critical question addressed by Kearns et al [1] in this issue of European Urology is whether variant SNP status has relevance to patient outcome and clinical management beyond simple higher risk of disease incidence. The authors assess the relationship between prostate cancer upgrading in surgical and active surveillance (AS) cohorts and the 23 single SNP variants identified using the Collaborative Oncological Gene-environment Study iCOGS chip [2]. The surgical cohort consisted of 950 patients who were categorised into those who continued to have Gleason score (GS) 6 disease (nonupgraded) and those who had higher-grade disease (GS 7, upgraded) following surgical pathology. The AS cohort consisted of 205 low-risk patients initially diagnosed as GS 6 with PSA <10 and 3 out of 12 or fewer cancer-containing cores. On subsequent biopsy, men continued to have GS 6 disease (nonupgraded) or had higher GS disease (upgraded). In the surgical series, only SNP rs11568818 at 11q22 remained significantly associated with upgrading following correction for multiple testing. In the AS cohort this allele was also present at significantly higher frequencies among upgraded men (p = 0.003). The observations of Kearns et al have potential relevance to our understanding of the mechanisms of disease" @default.
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- W1910365967 date "2016-02-01" @default.
- W1910365967 modified "2023-09-27" @default.
- W1910365967 title "Prostate Single Nucleotide Polymorphism Provides a Crucial Clue to Cancer Aggression in Active Surveillance Patients" @default.
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- W1910365967 doi "https://doi.org/10.1016/j.eururo.2015.09.038" @default.
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