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• W191052610 abstract "The antihyperglycemic and antinociceptive activities of methanolic extract of Tagetes patula leaves were studied in Swiss albino mice, respectively, through oral glucose tolerance tests, and acetic acid-induced gastric pain with concomitant abdominal constrictions. In oral glucose tolerance tests, the extract at doses of 100, 200 and 400 mg per kg body weight reduced the increase in blood glucose concentrations in glucose-loaded mice by 27.9, 30.6, and 36.5%, respectively. The results were statistically significant compared to control animals at all the three afore-mentioned doses. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced increases in blood glucose concentrations by 41.6%. Thus the extract demonstrated strong antihyperglycemic activity, which although not so potent as glibenclamide, at least merits further scientific studies towards isolation and identification of any antihyperhyperglycemic constituent(s) present in leaves. In antinociceptive activity tests conducted with acetic acid-induced gastric pain in mice model, the extract, when administered at doses of 50, 100, 200 and 400 mg per kg body weight, reduced the number of gastric pain-induced abdominal constrictions in mice, respectively, by 50.0, 54.2, 62.5 and 66.7%. A standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight, reduced the number of abdominal constrictions in gastric pain induced mice by 37.5%. The results thus demonstrate that the leaf extract contains component(s) with more potent antinociceptive potential than that of aspirin. Overall, the results validate the folk medicinal uses in Bangladesh of the leaves for reduction of blood sugar in diabetic patients and for alleviation of pain." @default.
• W191052610 created "2016-06-24" @default.
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• W191052610 date "2013-01-01" @default.
• W191052610 modified "2023-09-26" @default.
• W191052610 title "Tagetes patula L. (Asteraceae): an evaluation of antihyperglycemic and antinociceptive activity of methanolic extract of leaves." @default.
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