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- W1910619504 abstract "To investigate interactions between vitamin B-6 and fatty acid metabolism, male Wistar rats were fed a vitamin B-6 (B-6)–deficient diet consisting of 70% vitamin-free casein and 10% perilla oil [∼63% α-linolenic acid, (n-3)] for 5 wk. The amounts of linoleic acid (n-6) and arachidonic acid (n-6) in the B-6–deficient group changed only slightly compared with those in a pair-fed control group. The amount of linoleic acid increased and arachidonic acid decreased in the plasma total lipid fraction, and the ratios of both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the B-6–deficient group were significantly lower than for the controls. The ratios of α-linolenic acid and EPA were higher, and DHA lower, in the B-6–deficient group than in the pair-fed control group in the total lipid as well as phospholipid fractions in liver microsomes. The activity of Δ6-desaturase was significantly lower in the B-6–deficient group than in the pair-fed control group (∼64%), and acyl-CoA oxidase activity, an initial enzyme of the peroxisomal β-oxidation pathway, was reduced by ∼80% in the B-6–deficient group. These data suggest that B-6 deficiencies impair the metabolism of (n-3) PUFA from α-linolenic acid to EPA and DHA with the most pronounced reduction in the production of DHA." @default.
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- W1910619504 date "2000-02-01" @default.
- W1910619504 modified "2023-10-10" @default.
- W1910619504 title "Effects of Vitamin B-6 on (n-3) Polyunsaturated Fatty Acid Metabolism" @default.
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- W1910619504 doi "https://doi.org/10.1093/jn/130.2.333s" @default.
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