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- W191068927 endingPage "215" @default.
- W191068927 startingPage "193" @default.
- W191068927 abstract "Environmental or emotional challenge triggers a cascading series of responses collectively termed the “stress response”. Acute activation of the stress response modulates many aspects of physiology, including the immune system. Hans Seyle, the founding father of the concept of “biologic stress”, proposed in the 1900s that tissues release “alarm signals” in response to local and/or systemic challenge, and that these signals can initiate and direct inflammatory responses. There is a renewed interest in the investigation of tissue alarm signals and such signals have been coined “danger signals”, “DAMPS” (danger associated molecular patterns) and “hidden-self recognition signals”. This chapter focuses on heat shock protein 72 (Hsp72) as one potential alarm signal. Activation of the systemic stress response and the release of norepinephrine from sympathetic nerve terminals, stimulates the release of endogenous Hsp72 into the blood. We hypothesize that the tissue source of in vivo released Hsp72 is the small intestine, and that NE binds to alpha1 adrenergic receptors expressed on intestinal epithelial cells triggering the release of Hsp72 into the blood. Furthermore, we hypothesize that lipopolysaccharide derived from endogenous gut microflora binds Hsp72, and that the extracellular Hsp72-LPS complex may contribute to stress-associated modulation of in vivo inflammatory processes" @default.
- W191068927 created "2016-06-24" @default.
- W191068927 creator A5040373664 @default.
- W191068927 creator A5040394486 @default.
- W191068927 creator A5078597412 @default.
- W191068927 date "2009-11-25" @default.
- W191068927 modified "2023-09-26" @default.
- W191068927 title "In Vivo Tissue Source and Releasing Signal for Endogenous Extracellular Hsp72" @default.
- W191068927 cites W1483175931 @default.
- W191068927 cites W1504160997 @default.
- W191068927 cites W1515599953 @default.
- W191068927 cites W1518351006 @default.
- W191068927 cites W1534496719 @default.
- W191068927 cites W1547018200 @default.
- W191068927 cites W1555650656 @default.
- W191068927 cites W1574881121 @default.
- W191068927 cites W1584629476 @default.
- W191068927 cites W1585801143 @default.
- W191068927 cites W1586678823 @default.
- W191068927 cites W1587522694 @default.
- W191068927 cites W1591714343 @default.
- W191068927 cites W162757016 @default.
- W191068927 cites W1655860314 @default.
- W191068927 cites W1676263233 @default.
- W191068927 cites W1677028919 @default.
- W191068927 cites W1792761395 @default.
- W191068927 cites W1965486589 @default.
- W191068927 cites W1967669195 @default.
- W191068927 cites W1970497986 @default.
- W191068927 cites W1970620887 @default.
- W191068927 cites W1971756409 @default.
- W191068927 cites W1974287260 @default.
- W191068927 cites W1981654979 @default.
- W191068927 cites W1981932944 @default.
- W191068927 cites W1982297066 @default.
- W191068927 cites W1982494444 @default.
- W191068927 cites W1985494192 @default.
- W191068927 cites W1988767905 @default.
- W191068927 cites W1990249993 @default.
- W191068927 cites W1990736267 @default.
- W191068927 cites W1991832915 @default.
- W191068927 cites W1991861649 @default.
- W191068927 cites W1996486842 @default.
- W191068927 cites W2000109838 @default.
- W191068927 cites W2001018483 @default.
- W191068927 cites W2001524048 @default.
- W191068927 cites W2001719540 @default.
- W191068927 cites W2005053745 @default.
- W191068927 cites W2005570998 @default.
- W191068927 cites W2006104618 @default.
- W191068927 cites W2006285141 @default.
- W191068927 cites W2007196324 @default.
- W191068927 cites W2008206181 @default.
- W191068927 cites W2008956690 @default.
- W191068927 cites W2011641581 @default.
- W191068927 cites W2012451587 @default.
- W191068927 cites W2012588209 @default.
- W191068927 cites W2016534929 @default.
- W191068927 cites W2018549526 @default.
- W191068927 cites W2019499844 @default.
- W191068927 cites W2019573101 @default.
- W191068927 cites W2023395434 @default.
- W191068927 cites W2023746083 @default.
- W191068927 cites W2024982644 @default.
- W191068927 cites W2028432878 @default.
- W191068927 cites W2032942842 @default.
- W191068927 cites W2034052955 @default.
- W191068927 cites W2037404930 @default.
- W191068927 cites W2038204417 @default.
- W191068927 cites W2038270610 @default.
- W191068927 cites W2041616174 @default.
- W191068927 cites W2044644799 @default.
- W191068927 cites W2049028661 @default.
- W191068927 cites W2051763866 @default.
- W191068927 cites W2052791681 @default.
- W191068927 cites W2053006267 @default.
- W191068927 cites W2053848713 @default.
- W191068927 cites W2054726751 @default.
- W191068927 cites W2055132644 @default.
- W191068927 cites W2063956958 @default.
- W191068927 cites W2066368991 @default.
- W191068927 cites W2067414008 @default.
- W191068927 cites W2071691633 @default.
- W191068927 cites W2073204639 @default.
- W191068927 cites W2073476857 @default.
- W191068927 cites W2073547744 @default.
- W191068927 cites W2074103950 @default.
- W191068927 cites W2079757782 @default.
- W191068927 cites W2082601560 @default.
- W191068927 cites W2082793851 @default.
- W191068927 cites W2083419397 @default.
- W191068927 cites W2083682196 @default.
- W191068927 cites W2084407626 @default.
- W191068927 cites W2084462944 @default.
- W191068927 cites W2085765746 @default.
- W191068927 cites W2087896459 @default.
- W191068927 cites W2090025033 @default.
- W191068927 cites W2090792496 @default.