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- W1910757457 endingPage "557" @default.
- W1910757457 startingPage "547" @default.
- W1910757457 abstract "ABSTRACT The recent Ebola outbreak in West Africa highlights the need to improve our understanding of why viral hemorrhagic fevers (VHFs) are so devastating. There is a requirement to generate effective prophylactics, such as vaccines, and therapies, especially those that are effective postsymptomatically. For a range of pathogens, it appears that overstimulation of pro-inflammatory cytokines, the ‘cytokine storm’, causes serious immunopathology in patients. In this review, we will focus on the cytokine response following infection by representatives of the viruses which can cause VHF: Ebola virus and Marburg virus, Crimean–Congo hemorrhagic fever virus, Dengue virus, Junin and Lassa virus. Specifically, the role of the cytokine storm in causing VHF and the use of therapeutic immunomodulatory compounds to help treat these fatal and debilitating diseases will be explored." @default.
- W1910757457 created "2016-06-24" @default.
- W1910757457 creator A5054243424 @default.
- W1910757457 creator A5083848854 @default.
- W1910757457 creator A5091340040 @default.
- W1910757457 date "2015-05-01" @default.
- W1910757457 modified "2023-09-25" @default.
- W1910757457 title "Cytokines and viral hemorrhagic fever: potential for therapeutic intervention" @default.
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- W1910757457 doi "https://doi.org/10.2217/fvl.15.5" @default.
- W1910757457 hasPublicationYear "2015" @default.
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