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• W1911193661 abstract "Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions linking adjacent cells. Septal junctions and channels in the septal peptidoglycan are likely filled with septal junction complexes. While possible proteinaceous factors involved in septal junction formation, SepJ (FraG), FraC, and FraD, have been identified, little is known about peptidoglycan channel formation and septal junction complex anchoring to the peptidoglycan. We describe a factor, SjcF1, involved in regulation of septal junction channel formation in the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. SjcF1 interacts with the peptidoglycan layer through two peptidoglycan-binding domains and is localized throughout the cell periphery but at higher levels in the intercellular septa. A strain with an insertion in sjcF1 was not affected in peptidoglycan synthesis but showed an altered morphology of the septal peptidoglycan channels, which were significantly wider in the mutant than in the wild type. The mutant was impaired in intercellular exchange of a fluorescent probe to a similar extent as a sepJ deletion mutant. SjcF1 additionally bears an SH3 domain for protein-protein interactions. SH3 binding domains were identified in SepJ and FraC, and evidence for interaction of SjcF1 with both SepJ and FraC was obtained. SjcF1 represents a novel protein involved in structuring the peptidoglycan layer, which links peptidoglycan channel formation to septal junction complex function in multicellular cyanobacteria. Nonetheless, based on its subcellular distribution, this might not be the only function of SjcF1.Cell-cell communication is central not only for eukaryotic but also for multicellular prokaryotic systems. Principles of intercellular communication are well established for eukaryotes, but the mechanisms and components involved in bacteria are just emerging. Filamentous heterocyst-forming cyanobacteria behave as multicellular organisms and represent an excellent model to study prokaryotic cell-cell communication. A path for intercellular metabolite exchange appears to involve transfer through molecular structures termed septal junctions. They are reminiscent of metazoan gap junctions that directly link adjacent cells. In cyanobacteria, such structures need to traverse the peptidoglycan layers in the intercellular septa of the filament. Here we describe a factor involved in the formation of channels across the septal peptidoglycan layers, thus contributing to the multicellular behavior of these organisms." @default.
• W1911193661 created "2016-06-24" @default.
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• W1911193661 date "2015-09-01" @default.
• W1911193661 modified "2023-10-18" @default.
• W1911193661 title "The Peptidoglycan-Binding Protein SjcF1 Influences Septal Junction Function and Channel Formation in the Filamentous Cyanobacterium <i>Anabaena</i>" @default.
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• W1911193661 cites W1588401032 @default.
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• W1911193661 cites W1809761089 @default.
• W1911193661 cites W1885573734 @default.
• W1911193661 cites W1919668376 @default.
• W1911193661 cites W1963731232 @default.
• W1911193661 cites W1964390748 @default.
• W1911193661 cites W1965244951 @default.
• W1911193661 cites W1968809164 @default.
• W1911193661 cites W1971333632 @default.
• W1911193661 cites W1971349734 @default.
• W1911193661 cites W1971681094 @default.
• W1911193661 cites W1981554687 @default.
• W1911193661 cites W1988925120 @default.
• W1911193661 cites W1991093562 @default.
• W1911193661 cites W1998658230 @default.
• W1911193661 cites W2004549388 @default.
• W1911193661 cites W2011187599 @default.
• W1911193661 cites W2018727865 @default.
• W1911193661 cites W2024230891 @default.
• W1911193661 cites W2026182281 @default.
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• W1911193661 cites W2048316770 @default.
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• W1911193661 cites W2072864716 @default.
• W1911193661 cites W2073306537 @default.
• W1911193661 cites W2080114750 @default.
• W1911193661 cites W2080661489 @default.
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• W1911193661 cites W2092247420 @default.
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• W1911193661 doi "https://doi.org/10.1128/mbio.00376-15" @default.
• W1911193661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4488944" @default.
• W1911193661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26126850" @default.
• W1911193661 hasPublicationYear "2015" @default.
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