Matches in SemOpenAlex for { <https://semopenalex.org/work/W1911450008> ?p ?o ?g. }
- W1911450008 endingPage "75" @default.
- W1911450008 startingPage "1767" @default.
- W1911450008 abstract "Serum anti-p53 antibodies (p53-Abs) may be surrogate markers for both p53 alterations and preclinical cancer. Ancillary to a prospective trial to abate progressive development of clinical stages of chronic obstructive pulmonary disease, we conducted a retrospective, nested case-control study. Twenty-three cases were diagnosed with cancer during the trial. Enzyme immunoassay, immunoblotting, and immunoprecipitation were used to detect p53-Abs in serum, immunohistochemistry (IHC) to detect p53 accumulation, and single-strand conformation polymorphism and DNA sequencing to detect p53 mutations in tumor samples. p53-Abs were detected by three types of assays in five (23%) of the cancer patients, 80% of whom had detectable p53-Abs before diagnosis: 2 lung cancers (7 and 6 months before), 1 prostate cancer (11 months), and 1 breast cancer (5 months). Four Ab-positive patients had IHC-positive tumors. Two of 4 Ab-positive patients and 2 of 14 Ab-negative had p53 missense mutations or base pair deletion and IHC-positive tumors. The 44 noncancer COPD controls, matched with the cancer cases for age, gender, and smoking habits, were negative for p53-Abs. These results indicate that p53-Abs may facilitate the early diagnosis of cancer in a subset of smokers with chronic obstructive pulmonary disease who are at an increased cancer risk." @default.
- W1911450008 created "2016-06-24" @default.
- W1911450008 creator A5002051898 @default.
- W1911450008 creator A5016821984 @default.
- W1911450008 creator A5034195605 @default.
- W1911450008 creator A5049469115 @default.
- W1911450008 creator A5051313809 @default.
- W1911450008 creator A5052292428 @default.
- W1911450008 creator A5054026406 @default.
- W1911450008 creator A5058147268 @default.
- W1911450008 creator A5071847625 @default.
- W1911450008 creator A5079790766 @default.
- W1911450008 creator A5089560851 @default.
- W1911450008 creator A5090052664 @default.
- W1911450008 date "1996-10-01" @default.
- W1911450008 modified "2023-10-06" @default.
- W1911450008 title "Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer." @default.
- W1911450008 cites W1499161907 @default.
- W1911450008 cites W1499849678 @default.
- W1911450008 cites W1552426876 @default.
- W1911450008 cites W1590126154 @default.
- W1911450008 cites W1819031394 @default.
- W1911450008 cites W1844199473 @default.
- W1911450008 cites W1870369688 @default.
- W1911450008 cites W1974145895 @default.
- W1911450008 cites W1986685145 @default.
- W1911450008 cites W1992836428 @default.
- W1911450008 cites W1993358791 @default.
- W1911450008 cites W2016759398 @default.
- W1911450008 cites W2016793236 @default.
- W1911450008 cites W2017293277 @default.
- W1911450008 cites W2034639401 @default.
- W1911450008 cites W2035769098 @default.
- W1911450008 cites W2048842466 @default.
- W1911450008 cites W2058865482 @default.
- W1911450008 cites W2066059886 @default.
- W1911450008 cites W2074091025 @default.
- W1911450008 cites W2075847417 @default.
- W1911450008 cites W2085295693 @default.
- W1911450008 cites W2085318522 @default.
- W1911450008 cites W2095356554 @default.
- W1911450008 cites W2105327099 @default.
- W1911450008 cites W2111703821 @default.
- W1911450008 cites W2114473143 @default.
- W1911450008 cites W2124840772 @default.
- W1911450008 cites W2135071278 @default.
- W1911450008 cites W2162059976 @default.
- W1911450008 cites W2165286908 @default.
- W1911450008 cites W74437908 @default.
- W1911450008 cites W2159223931 @default.
- W1911450008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9816128" @default.
- W1911450008 hasPublicationYear "1996" @default.
- W1911450008 type Work @default.
- W1911450008 sameAs 1911450008 @default.
- W1911450008 citedByCount "43" @default.
- W1911450008 countsByYear W19114500082012 @default.
- W1911450008 countsByYear W19114500082014 @default.
- W1911450008 countsByYear W19114500082016 @default.
- W1911450008 countsByYear W19114500082017 @default.
- W1911450008 countsByYear W19114500082019 @default.
- W1911450008 countsByYear W19114500082020 @default.
- W1911450008 countsByYear W19114500082022 @default.
- W1911450008 crossrefType "journal-article" @default.
- W1911450008 hasAuthorship W1911450008A5002051898 @default.
- W1911450008 hasAuthorship W1911450008A5016821984 @default.
- W1911450008 hasAuthorship W1911450008A5034195605 @default.
- W1911450008 hasAuthorship W1911450008A5049469115 @default.
- W1911450008 hasAuthorship W1911450008A5051313809 @default.
- W1911450008 hasAuthorship W1911450008A5052292428 @default.
- W1911450008 hasAuthorship W1911450008A5054026406 @default.
- W1911450008 hasAuthorship W1911450008A5058147268 @default.
- W1911450008 hasAuthorship W1911450008A5071847625 @default.
- W1911450008 hasAuthorship W1911450008A5079790766 @default.
- W1911450008 hasAuthorship W1911450008A5089560851 @default.
- W1911450008 hasAuthorship W1911450008A5090052664 @default.
- W1911450008 hasConcept C121608353 @default.
- W1911450008 hasConcept C126322002 @default.
- W1911450008 hasConcept C142724271 @default.
- W1911450008 hasConcept C143998085 @default.
- W1911450008 hasConcept C159654299 @default.
- W1911450008 hasConcept C203014093 @default.
- W1911450008 hasConcept C204232928 @default.
- W1911450008 hasConcept C2776256026 @default.
- W1911450008 hasConcept C2780192828 @default.
- W1911450008 hasConcept C71924100 @default.
- W1911450008 hasConcept C90924648 @default.
- W1911450008 hasConceptScore W1911450008C121608353 @default.
- W1911450008 hasConceptScore W1911450008C126322002 @default.
- W1911450008 hasConceptScore W1911450008C142724271 @default.
- W1911450008 hasConceptScore W1911450008C143998085 @default.
- W1911450008 hasConceptScore W1911450008C159654299 @default.
- W1911450008 hasConceptScore W1911450008C203014093 @default.
- W1911450008 hasConceptScore W1911450008C204232928 @default.
- W1911450008 hasConceptScore W1911450008C2776256026 @default.
- W1911450008 hasConceptScore W1911450008C2780192828 @default.
- W1911450008 hasConceptScore W1911450008C71924100 @default.
- W1911450008 hasConceptScore W1911450008C90924648 @default.
- W1911450008 hasIssue "10" @default.