FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1911509246> ?p ?o ?g. }

• W1911509246 endingPage "820" @default.
• W1911509246 startingPage "807" @default.
• W1911509246 abstract "Abstract Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative traits. However, conflicting results from various types of models have been obtained. While classical analyses assuming a large number of independent additive loci with individually small effects indicated that no genetic variation is preserved under stabilizing selection, several analyses of two-locus models showed the contrary. We perform a complete analysis of a generalization of Wright’s two-locus quadratic-optimum model and investigate numerically the ability of quadratic stabilizing selection to maintain genetic variation in additive quantitative traits controlled by up to five loci. A statistical approach is employed by choosing randomly 4000 parameter sets (allelic effects, recombination rates, and strength of selection) for a given number of loci. For each parameter set we iterate the recursion equations that describe the dynamics of gamete frequencies starting from 20 randomly chosen initial conditions until an equilibrium is reached, record the quantities of interest, and calculate their corresponding mean values. As the number of loci increases from two to five, the fraction of the genome expected to be polymorphic declines surprisingly rapidly, and the loci that are polymorphic increasingly are those with small effects on the trait. As a result, the genetic variance expected to be maintained under stabilizing selection decreases very rapidly with increased number of loci. The equilibrium structure expected under stabilizing selection on an additive trait differs markedly from that expected under selection with no constraints on genotypic fitness values. The expected genetic variance, the expected polymorphic fraction of the genome, as well as other quantities of interest, are only weakly dependent on the selection intensity and the level of recombination." @default.
• W1911509246 created "2016-06-24" @default.
• W1911509246 creator A5008531591 @default.
• W1911509246 creator A5034270250 @default.
• W1911509246 date "1999-06-01" @default.
• W1911509246 modified "2023-10-17" @default.
• W1911509246 title "Genetic Variation Maintained in Multilocus Models of Additive Quantitative Traits Under Stabilizing Selection" @default.
• W1911509246 cites W1559579788 @default.
• W1911509246 cites W1822425766 @default.
• W1911509246 cites W1877460931 @default.
• W1911509246 cites W1885528178 @default.
• W1911509246 cites W1910648479 @default.
• W1911509246 cites W1931233112 @default.
• W1911509246 cites W1956140554 @default.
• W1911509246 cites W1978697143 @default.
• W1911509246 cites W1981288860 @default.
• W1911509246 cites W1991285631 @default.
• W1911509246 cites W1997068972 @default.
• W1911509246 cites W1999802103 @default.
• W1911509246 cites W2004778468 @default.
• W1911509246 cites W2006199818 @default.
• W1911509246 cites W2010904972 @default.
• W1911509246 cites W2030611127 @default.
• W1911509246 cites W2045522121 @default.
• W1911509246 cites W2047022937 @default.
• W1911509246 cites W2050048406 @default.
• W1911509246 cites W2052609406 @default.
• W1911509246 cites W2055398052 @default.
• W1911509246 cites W2066290609 @default.
• W1911509246 cites W2090000755 @default.
• W1911509246 cites W2118925205 @default.
• W1911509246 cites W2140482783 @default.
• W1911509246 cites W2143673411 @default.
• W1911509246 cites W2153359028 @default.
• W1911509246 cites W2159707462 @default.
• W1911509246 cites W2323460756 @default.
• W1911509246 cites W3171836044 @default.
• W1911509246 doi "https://doi.org/10.1093/genetics/152.2.807" @default.
• W1911509246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460636" @default.
• W1911509246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10353920" @default.
• W1911509246 hasPublicationYear "1999" @default.
• W1911509246 type Work @default.
• W1911509246 sameAs 1911509246 @default.
• W1911509246 citedByCount "55" @default.
• W1911509246 countsByYear W19115092462012 @default.
• W1911509246 countsByYear W19115092462013 @default.
• W1911509246 countsByYear W19115092462014 @default.
• W1911509246 countsByYear W19115092462015 @default.
• W1911509246 countsByYear W19115092462016 @default.
• W1911509246 countsByYear W19115092462017 @default.
• W1911509246 countsByYear W19115092462018 @default.
• W1911509246 countsByYear W19115092462019 @default.
• W1911509246 countsByYear W19115092462021 @default.
• W1911509246 countsByYear W19115092462023 @default.
• W1911509246 crossrefType "journal-article" @default.
• W1911509246 hasAuthorship W1911509246A5008531591 @default.
• W1911509246 hasAuthorship W1911509246A5034270250 @default.
• W1911509246 hasBestOaLocation W19115092461 @default.
• W1911509246 hasConcept C104317684 @default.
• W1911509246 hasConcept C105795698 @default.
• W1911509246 hasConcept C106934330 @default.
• W1911509246 hasConcept C154945302 @default.
• W1911509246 hasConcept C199360897 @default.
• W1911509246 hasConcept C2262138 @default.
• W1911509246 hasConcept C2992519594 @default.
• W1911509246 hasConcept C33923547 @default.
• W1911509246 hasConcept C41008148 @default.
• W1911509246 hasConcept C46097333 @default.
• W1911509246 hasConcept C51255272 @default.
• W1911509246 hasConcept C54355233 @default.
• W1911509246 hasConcept C61727976 @default.
• W1911509246 hasConcept C68873052 @default.
• W1911509246 hasConcept C75268714 @default.
• W1911509246 hasConcept C78458016 @default.
• W1911509246 hasConcept C81917197 @default.
• W1911509246 hasConcept C81941488 @default.
• W1911509246 hasConcept C84597430 @default.
• W1911509246 hasConcept C86803240 @default.
• W1911509246 hasConcept C9287583 @default.
• W1911509246 hasConceptScore W1911509246C104317684 @default.
• W1911509246 hasConceptScore W1911509246C105795698 @default.
• W1911509246 hasConceptScore W1911509246C106934330 @default.
• W1911509246 hasConceptScore W1911509246C154945302 @default.
• W1911509246 hasConceptScore W1911509246C199360897 @default.
• W1911509246 hasConceptScore W1911509246C2262138 @default.
• W1911509246 hasConceptScore W1911509246C2992519594 @default.
• W1911509246 hasConceptScore W1911509246C33923547 @default.
• W1911509246 hasConceptScore W1911509246C41008148 @default.
• W1911509246 hasConceptScore W1911509246C46097333 @default.
• W1911509246 hasConceptScore W1911509246C51255272 @default.
• W1911509246 hasConceptScore W1911509246C54355233 @default.
• W1911509246 hasConceptScore W1911509246C61727976 @default.
• W1911509246 hasConceptScore W1911509246C68873052 @default.
• W1911509246 hasConceptScore W1911509246C75268714 @default.
• W1911509246 hasConceptScore W1911509246C78458016 @default.
• W1911509246 hasConceptScore W1911509246C81917197 @default.
• W1911509246 hasConceptScore W1911509246C81941488 @default.
• W1911509246 hasConceptScore W1911509246C84597430 @default.

• next