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• W1911566730 endingPage "9021" @default.
• W1911566730 startingPage "9016" @default.
• W1911566730 abstract "The heterotrimeric SecY translocon complex is required for the cotranslational assembly of membrane proteins in bacteria and archaea. The insertion of transmembrane (TM) segments during nascent-chain passage through the translocon is generally viewed as a simple partitioning process between the water-filled translocon and membrane lipid bilayer, suggesting that partitioning is driven by the hydrophobic effect. Indeed, the apparent free energy of partitioning of unnatural aliphatic amino acids on TM segments is proportional to accessible surface area, which is a hallmark of the hydrophobic effect [Öjemalm K, et al. (2011) Proc Natl Acad Sci USA 108(31):E359-E364]. However, the apparent partitioning solvation parameter is less than one-half the value expected for simple bulk partitioning, suggesting that the water in the translocon departs from bulk behavior. To examine the state of water in a SecY translocon complex embedded in a lipid bilayer, we carried out all-atom molecular-dynamics simulations of the Pyrococcus furiosus SecYE, which was determined to be in a primed open state [Egea PF, Stroud RM (2010) Proc Natl Acad Sci USA 107(40):17182-17187]. Remarkably, SecYE remained in this state throughout our 450-ns simulation. Water molecules within SecY exhibited anomalous diffusion, had highly retarded rotational dynamics, and aligned their dipoles along the SecY transmembrane axis. The translocon is therefore not a simple water-filled pore, which raises the question of how anomalous water behavior affects the mechanism of translocon function and, more generally, the partitioning of hydrophobic molecules. Because large water-filled cavities are found in many membrane proteins, our findings may have broader implications." @default.
• W1911566730 created "2016-06-24" @default.
• W1911566730 creator A5038985855 @default.
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• W1911566730 creator A5054892499 @default.
• W1911566730 date "2015-07-02" @default.
• W1911566730 modified "2023-09-26" @default.
• W1911566730 title "Anomalous behavior of water inside the SecY translocon" @default.
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• W1911566730 doi "https://doi.org/10.1073/pnas.1424483112" @default.
• W1911566730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4517221" @default.
• W1911566730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26139523" @default.
• W1911566730 hasPublicationYear "2015" @default.
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