FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1911726069> ?p ?o ?g. }

• W1911726069 abstract "Abstract Background Cervical Cancer (CC) exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of Slit-Robo pathway genes. However, no candidate tumor suppressor genes at these regions have been identified so far. Slit family of secreted proteins modulates chemokine-induced cell migration of distinct somatic cell types. Slit genes mediate their effect by binding to its receptor Roundabout (Robo). These genes have shown to be inactivated by promoter hypermethylation in a number of human cancers. Results To test whether Slit-Robo pathway genes are targets of inactivation at these sites of deletion, we examined promoter hypermethylation of SLIT1 , SLIT2 , SLIT3 , ROBO1 , and ROBO3 genes in invasive CC and its precursor lesions. We identified a high frequency of promoter hypermethylation in all the Slit-Robo genes resulting in down regulated gene expression in invasive CC, but the inhibitors of DNA methylation and histone deacetylases (HDACs) in CC cell lines failed to effectively reactivate the down-regulated expression. These results suggest a complex mechanism of inactivation in the Slit-Robo pathway in CC. By analysis of cervical precancerous lesions, we further show that promoter hypermethylation of Slit-Robo pathway occurs early in tumor progression. Conclusion Taken together, these findings suggest that epigenetic alterations of Slit-Robo pathway genes (i) play a role in CC development, (ii) further delineation of molecular basis of promoter methylation-mediated gene regulation provides a potential basis for epigenetic-based therapy in advanced stage CC, and (iii) form epigenetic signatures to identify precancerous lesions at risk to progression." @default.
• W1911726069 created "2016-06-24" @default.
• W1911726069 creator A5002615131 @default.
• W1911726069 creator A5007605375 @default.
• W1911726069 creator A5010765825 @default.
• W1911726069 creator A5036202264 @default.
• W1911726069 creator A5052394856 @default.
• W1911726069 creator A5066939454 @default.
• W1911726069 creator A5080521934 @default.
• W1911726069 creator A5080947445 @default.
• W1911726069 creator A5091159415 @default.
• W1911726069 date "2006-05-15" @default.
• W1911726069 modified "2023-10-16" @default.
• W1911726069 title "Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression" @default.
• W1911726069 cites W1556996865 @default.
• W1911726069 cites W1561902389 @default.
• W1911726069 cites W1579447084 @default.
• W1911726069 cites W1945270539 @default.
• W1911726069 cites W1955158742 @default.
• W1911726069 cites W1963567995 @default.
• W1911726069 cites W1977937744 @default.
• W1911726069 cites W1986986419 @default.
• W1911726069 cites W1994465394 @default.
• W1911726069 cites W2021622839 @default.
• W1911726069 cites W2026177356 @default.
• W1911726069 cites W2026372288 @default.
• W1911726069 cites W2036734716 @default.
• W1911726069 cites W2038835900 @default.
• W1911726069 cites W2042473783 @default.
• W1911726069 cites W2050041497 @default.
• W1911726069 cites W2058667428 @default.
• W1911726069 cites W2058852421 @default.
• W1911726069 cites W2061467267 @default.
• W1911726069 cites W2076731647 @default.
• W1911726069 cites W2078374322 @default.
• W1911726069 cites W2094964650 @default.
• W1911726069 cites W2098765233 @default.
• W1911726069 cites W2119063974 @default.
• W1911726069 cites W2120436117 @default.
• W1911726069 cites W2128686282 @default.
• W1911726069 cites W2138859400 @default.
• W1911726069 cites W2145130556 @default.
• W1911726069 cites W2159173286 @default.
• W1911726069 cites W2163557331 @default.
• W1911726069 cites W3023305311 @default.
• W1911726069 doi "https://doi.org/10.1186/1476-4598-5-16" @default.
• W1911726069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1482714" @default.
• W1911726069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16700909" @default.
• W1911726069 hasPublicationYear "2006" @default.
• W1911726069 type Work @default.
• W1911726069 sameAs 1911726069 @default.
• W1911726069 citedByCount "127" @default.
• W1911726069 countsByYear W19117260692012 @default.
• W1911726069 countsByYear W19117260692013 @default.
• W1911726069 countsByYear W19117260692014 @default.
• W1911726069 countsByYear W19117260692015 @default.
• W1911726069 countsByYear W19117260692016 @default.
• W1911726069 countsByYear W19117260692017 @default.
• W1911726069 countsByYear W19117260692018 @default.
• W1911726069 countsByYear W19117260692019 @default.
• W1911726069 countsByYear W19117260692020 @default.
• W1911726069 countsByYear W19117260692021 @default.
• W1911726069 countsByYear W19117260692022 @default.
• W1911726069 countsByYear W19117260692023 @default.
• W1911726069 crossrefType "journal-article" @default.
• W1911726069 hasAuthorship W1911726069A5002615131 @default.
• W1911726069 hasAuthorship W1911726069A5007605375 @default.
• W1911726069 hasAuthorship W1911726069A5010765825 @default.
• W1911726069 hasAuthorship W1911726069A5036202264 @default.
• W1911726069 hasAuthorship W1911726069A5052394856 @default.
• W1911726069 hasAuthorship W1911726069A5066939454 @default.
• W1911726069 hasAuthorship W1911726069A5080521934 @default.
• W1911726069 hasAuthorship W1911726069A5080947445 @default.
• W1911726069 hasAuthorship W1911726069A5091159415 @default.
• W1911726069 hasBestOaLocation W19117260691 @default.
• W1911726069 hasConcept C101762097 @default.
• W1911726069 hasConcept C104317684 @default.
• W1911726069 hasConcept C150194340 @default.
• W1911726069 hasConcept C190727270 @default.
• W1911726069 hasConcept C199215989 @default.
• W1911726069 hasConcept C33288867 @default.
• W1911726069 hasConcept C41091548 @default.
• W1911726069 hasConcept C502942594 @default.
• W1911726069 hasConcept C54355233 @default.
• W1911726069 hasConcept C64927066 @default.
• W1911726069 hasConcept C86803240 @default.
• W1911726069 hasConceptScore W1911726069C101762097 @default.
• W1911726069 hasConceptScore W1911726069C104317684 @default.
• W1911726069 hasConceptScore W1911726069C150194340 @default.
• W1911726069 hasConceptScore W1911726069C190727270 @default.
• W1911726069 hasConceptScore W1911726069C199215989 @default.
• W1911726069 hasConceptScore W1911726069C33288867 @default.
• W1911726069 hasConceptScore W1911726069C41091548 @default.
• W1911726069 hasConceptScore W1911726069C502942594 @default.
• W1911726069 hasConceptScore W1911726069C54355233 @default.
• W1911726069 hasConceptScore W1911726069C64927066 @default.
• W1911726069 hasConceptScore W1911726069C86803240 @default.
• W1911726069 hasIssue "1" @default.
• W1911726069 hasLocation W19117260691 @default.
• W1911726069 hasLocation W19117260692 @default.

• next