Matches in SemOpenAlex for { <https://semopenalex.org/work/W1911753375> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1911753375 endingPage "511" @default.
- W1911753375 startingPage "508" @default.
- W1911753375 abstract "In previous studies using the HPLC and avidin-binding assay, five unidentified avidin-binding substances were observed in human urine. The present study investigated the identity of these substances. Urine was collected before and after intravenous administration of 18.5 mumol biotin to healthy adults. Unknown substances 1 and 3 were initially identified as biotin sulfone and bisnorbiotin methyl ketone, respectively, by coelution with authentic standards on HPLC. Identities were confirmed by thin-layer chromatography and by derivatization with p-dimethyl-aminocinnamaldehyde. As expected for biotin metabolites, the urinary excretion of biotin sulfone and bisnorbiotin methyl ketone increased with biotin administration. The urinary excretion of biotin sulfone increased 21-fold from 0.2 nmol/h before to 4.2 nmol/h after administration; the excretion of bisnorbiotin methyl ketone increased 130-fold from 0.4 to 51.8 nmol/h. At presumed steady state in free-living subjects (n = 6), biotin sulfone and bisnorbiotin methyl ketone accounted for 3.6% and 7.9% of total biotin excretion, respectively. Traces of tetranorbiotin-l-sulfoxide were also identified by using thin-layer chromatography and derivatization with p-dimethylaminocinnamaldehyde. However, tetranorbiotin-l-sulfoxide was not detectable in urine by the HPLC and avidin-binding assay because this metabolite has weak avidin-binding affinity. We conclude that biotin sulfone and bisnorbiotin methyl ketone are present in measurable quantities in human urine; their quantitation should allow more accurate studies on human biotin metabolism and turnover." @default.
- W1911753375 created "2016-06-24" @default.
- W1911753375 creator A5019079377 @default.
- W1911753375 creator A5044003397 @default.
- W1911753375 creator A5064778502 @default.
- W1911753375 date "1997-02-01" @default.
- W1911753375 modified "2023-09-26" @default.
- W1911753375 title "Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-l-sulfoxide in human urine" @default.
- W1911753375 cites W1491713528 @default.
- W1911753375 cites W1545204869 @default.
- W1911753375 cites W1585675907 @default.
- W1911753375 cites W1684001256 @default.
- W1911753375 cites W1818763050 @default.
- W1911753375 cites W1966511331 @default.
- W1911753375 cites W1968735891 @default.
- W1911753375 cites W2026442894 @default.
- W1911753375 cites W2041233308 @default.
- W1911753375 cites W2050751927 @default.
- W1911753375 cites W2277851873 @default.
- W1911753375 cites W4230038894 @default.
- W1911753375 doi "https://doi.org/10.1093/ajcn/65.2.508" @default.
- W1911753375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9022537" @default.
- W1911753375 hasPublicationYear "1997" @default.
- W1911753375 type Work @default.
- W1911753375 sameAs 1911753375 @default.
- W1911753375 citedByCount "53" @default.
- W1911753375 countsByYear W19117533752012 @default.
- W1911753375 countsByYear W19117533752013 @default.
- W1911753375 countsByYear W19117533752014 @default.
- W1911753375 countsByYear W19117533752015 @default.
- W1911753375 countsByYear W19117533752018 @default.
- W1911753375 countsByYear W19117533752019 @default.
- W1911753375 countsByYear W19117533752020 @default.
- W1911753375 countsByYear W19117533752021 @default.
- W1911753375 countsByYear W19117533752022 @default.
- W1911753375 crossrefType "journal-article" @default.
- W1911753375 hasAuthorship W1911753375A5019079377 @default.
- W1911753375 hasAuthorship W1911753375A5044003397 @default.
- W1911753375 hasAuthorship W1911753375A5064778502 @default.
- W1911753375 hasBestOaLocation W19117533751 @default.
- W1911753375 hasConcept C10146269 @default.
- W1911753375 hasConcept C176406525 @default.
- W1911753375 hasConcept C178790620 @default.
- W1911753375 hasConcept C179998833 @default.
- W1911753375 hasConcept C185592680 @default.
- W1911753375 hasConcept C2776923573 @default.
- W1911753375 hasConcept C2777477808 @default.
- W1911753375 hasConcept C2777738585 @default.
- W1911753375 hasConcept C2778204606 @default.
- W1911753375 hasConcept C2778448320 @default.
- W1911753375 hasConcept C2778806918 @default.
- W1911753375 hasConcept C2780026642 @default.
- W1911753375 hasConcept C43617362 @default.
- W1911753375 hasConcept C55493867 @default.
- W1911753375 hasConceptScore W1911753375C10146269 @default.
- W1911753375 hasConceptScore W1911753375C176406525 @default.
- W1911753375 hasConceptScore W1911753375C178790620 @default.
- W1911753375 hasConceptScore W1911753375C179998833 @default.
- W1911753375 hasConceptScore W1911753375C185592680 @default.
- W1911753375 hasConceptScore W1911753375C2776923573 @default.
- W1911753375 hasConceptScore W1911753375C2777477808 @default.
- W1911753375 hasConceptScore W1911753375C2777738585 @default.
- W1911753375 hasConceptScore W1911753375C2778204606 @default.
- W1911753375 hasConceptScore W1911753375C2778448320 @default.
- W1911753375 hasConceptScore W1911753375C2778806918 @default.
- W1911753375 hasConceptScore W1911753375C2780026642 @default.
- W1911753375 hasConceptScore W1911753375C43617362 @default.
- W1911753375 hasConceptScore W1911753375C55493867 @default.
- W1911753375 hasIssue "2" @default.
- W1911753375 hasLocation W19117533751 @default.
- W1911753375 hasLocation W19117533752 @default.
- W1911753375 hasOpenAccess W1911753375 @default.
- W1911753375 hasPrimaryLocation W19117533751 @default.
- W1911753375 hasRelatedWork W118183763 @default.
- W1911753375 hasRelatedWork W1911753375 @default.
- W1911753375 hasRelatedWork W1970888742 @default.
- W1911753375 hasRelatedWork W1990253479 @default.
- W1911753375 hasRelatedWork W2008727242 @default.
- W1911753375 hasRelatedWork W2035747744 @default.
- W1911753375 hasRelatedWork W2078264376 @default.
- W1911753375 hasRelatedWork W2107750257 @default.
- W1911753375 hasRelatedWork W2385767697 @default.
- W1911753375 hasRelatedWork W2406364491 @default.
- W1911753375 hasVolume "65" @default.
- W1911753375 isParatext "false" @default.
- W1911753375 isRetracted "false" @default.
- W1911753375 magId "1911753375" @default.
- W1911753375 workType "article" @default.