FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912019839> ?p ?o ?g. }

• W1912019839 endingPage "36614" @default.
• W1912019839 startingPage "36603" @default.
• W1912019839 abstract "Experiments were performed in a modified microfluidic platform recapitulating part of the in vivo tumor microenvironment by co-culturing carcinoma cell aggregates embedded in a three-dimensional (3D) collagen scaffold with human umbilical vein endothelial cells (HUVECs). HUVECs were seeded in one channel of the device to initiate vessel-like structures in vitro prior to introducing the aggregates. The lung adenocarcinoma cell line A549 and the bladder carcinoma cell line T24 were tested. Dose-response assays of four drugs known to interfere with Epithelial Mesenchymal Transition (EMT) signaling pathways were quantified using relative dispersion as a metric of EMT progression. The presence of HUVECs in one channel induces cell dispersal in A549 which then can be inhibited by each of the four drugs. Complete inhibition of T24 aggregate dispersal, however, is not achieved with any single agent, although partial inhibition was observed with 10 μM of the Src inhibitor, AZD-0530. Almost complete inhibition of T24 dispersal in monoculture was achieved only when the four drugs were added in combination, each at 10 μM concentration. Coculture of T24 with HUVECs forfeits the almost-complete inhibition. The enhanced dispersal observed in the presence of HUVECs is a consequence of secretion of growth factors, including HGF and FGF-2, by endothelial cells. This 3D microfluidic co-culture platform provides an in vivo-like surrogate for anti-invasive and anti-metastatic drug screening. It will be particularly useful for defining combination therapies for aggressive tumors such as invasive bladder carcinoma." @default.
• W1912019839 created "2016-06-24" @default.
• W1912019839 creator A5024129262 @default.
• W1912019839 creator A5039283945 @default.
• W1912019839 creator A5047618524 @default.
• W1912019839 creator A5052386069 @default.
• W1912019839 creator A5087954362 @default.
• W1912019839 date "2015-10-08" @default.
• W1912019839 modified "2023-10-03" @default.
• W1912019839 title "Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment" @default.
• W1912019839 cites W1487498644 @default.
• W1912019839 cites W1542528628 @default.
• W1912019839 cites W1565998422 @default.
• W1912019839 cites W1954609198 @default.
• W1912019839 cites W1964081206 @default.
• W1912019839 cites W1966307963 @default.
• W1912019839 cites W1970920799 @default.
• W1912019839 cites W1997702899 @default.
• W1912019839 cites W2003291351 @default.
• W1912019839 cites W2005133216 @default.
• W1912019839 cites W2013625721 @default.
• W1912019839 cites W2013678879 @default.
• W1912019839 cites W2026548544 @default.
• W1912019839 cites W2042198997 @default.
• W1912019839 cites W2044031153 @default.
• W1912019839 cites W2045712888 @default.
• W1912019839 cites W2062265555 @default.
• W1912019839 cites W2064348302 @default.
• W1912019839 cites W2071359561 @default.
• W1912019839 cites W2076583198 @default.
• W1912019839 cites W2076782790 @default.
• W1912019839 cites W2079548558 @default.
• W1912019839 cites W2079876207 @default.
• W1912019839 cites W2117692326 @default.
• W1912019839 cites W2120656656 @default.
• W1912019839 cites W2138086500 @default.
• W1912019839 cites W2138536085 @default.
• W1912019839 cites W2142641037 @default.
• W1912019839 cites W2144744111 @default.
• W1912019839 cites W2152455647 @default.
• W1912019839 cites W2158776028 @default.
• W1912019839 cites W2160908941 @default.
• W1912019839 cites W2164618834 @default.
• W1912019839 cites W2167198989 @default.
• W1912019839 cites W2312752335 @default.
• W1912019839 doi "https://doi.org/10.18632/oncotarget.5464" @default.
• W1912019839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4742198" @default.
• W1912019839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26474384" @default.
• W1912019839 hasPublicationYear "2015" @default.
• W1912019839 type Work @default.
• W1912019839 sameAs 1912019839 @default.
• W1912019839 citedByCount "59" @default.
• W1912019839 countsByYear W19120198392015 @default.
• W1912019839 countsByYear W19120198392016 @default.
• W1912019839 countsByYear W19120198392017 @default.
• W1912019839 countsByYear W19120198392018 @default.
• W1912019839 countsByYear W19120198392019 @default.
• W1912019839 countsByYear W19120198392020 @default.
• W1912019839 countsByYear W19120198392021 @default.
• W1912019839 countsByYear W19120198392022 @default.
• W1912019839 countsByYear W19120198392023 @default.
• W1912019839 crossrefType "journal-article" @default.
• W1912019839 hasAuthorship W1912019839A5024129262 @default.
• W1912019839 hasAuthorship W1912019839A5039283945 @default.
• W1912019839 hasAuthorship W1912019839A5047618524 @default.
• W1912019839 hasAuthorship W1912019839A5052386069 @default.
• W1912019839 hasAuthorship W1912019839A5087954362 @default.
• W1912019839 hasBestOaLocation W19120198391 @default.
• W1912019839 hasConcept C121608353 @default.
• W1912019839 hasConcept C126322002 @default.
• W1912019839 hasConcept C142724271 @default.
• W1912019839 hasConcept C150903083 @default.
• W1912019839 hasConcept C185592680 @default.
• W1912019839 hasConcept C202751555 @default.
• W1912019839 hasConcept C203014093 @default.
• W1912019839 hasConcept C207001950 @default.
• W1912019839 hasConcept C2776107976 @default.
• W1912019839 hasConcept C2776256026 @default.
• W1912019839 hasConcept C2777411675 @default.
• W1912019839 hasConcept C2777546739 @default.
• W1912019839 hasConcept C2779013556 @default.
• W1912019839 hasConcept C3020616263 @default.
• W1912019839 hasConcept C502942594 @default.
• W1912019839 hasConcept C54355233 @default.
• W1912019839 hasConcept C553184892 @default.
• W1912019839 hasConcept C55493867 @default.
• W1912019839 hasConcept C71924100 @default.
• W1912019839 hasConcept C76419328 @default.
• W1912019839 hasConcept C81729549 @default.
• W1912019839 hasConcept C81885089 @default.
• W1912019839 hasConcept C86803240 @default.
• W1912019839 hasConcept C95444343 @default.
• W1912019839 hasConcept C98274493 @default.
• W1912019839 hasConceptScore W1912019839C121608353 @default.
• W1912019839 hasConceptScore W1912019839C126322002 @default.
• W1912019839 hasConceptScore W1912019839C142724271 @default.
• W1912019839 hasConceptScore W1912019839C150903083 @default.
• W1912019839 hasConceptScore W1912019839C185592680 @default.

• next