FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912088000> ?p ?o ?g. }

• W1912088000 endingPage "5115" @default.
• W1912088000 startingPage "5111" @default.
• W1912088000 abstract "Protein S is a vitamin K-dependent plasma protein. It functions as a cofactor to activated protein C in the inactivation of factors Va and VIIIa by limited proteolysis. Protein S is very sensitive to proteolysis by thrombin which reduces its calcium ion binding and leads to a loss of its cofactor activity. We have now determined the sequence of the 100 amino-terminal amino acid residues and localized the thrombin cleavage sites. Protein S contains 11 gamma-carboxyglutamic acid residues in the amino-terminal region (residues 1-36). This part of protein S is highly homologous to the corresponding parts in the other vitamin K-dependent clotting factors, whereas the region between residues 45 and 75 is not at all homologous to the other clotting factors. Thrombin cleaves two peptide bonds in this part of protein S, first at arginine 70 and then at arginine 52. The peptide containing residues 53-70 is released from protein S after thrombin cleavage. The amino-terminal fragment, residues 1-52, is linked to the large carboxyl-terminal fragment by a disulfide bond, which involves cysteine 47. After residue 78, protein S is again homologous to factors IX and X and to proteins C and Z, but not to prothrombin. Position 95 is occupied by a beta-hydroxyaspartic acid residue." @default.
• W1912088000 created "2016-06-24" @default.
• W1912088000 creator A5009459466 @default.
• W1912088000 creator A5047505231 @default.
• W1912088000 creator A5048301059 @default.
• W1912088000 date "1986-04-01" @default.
• W1912088000 modified "2023-10-16" @default.
• W1912088000 title "Localization of thrombin cleavage sites in the amino-terminal region of bovine protein S." @default.
• W1912088000 cites W110124829 @default.
• W1912088000 cites W1519587642 @default.
• W1912088000 cites W1522702062 @default.
• W1912088000 cites W1537891220 @default.
• W1912088000 cites W1559899200 @default.
• W1912088000 cites W1578912075 @default.
• W1912088000 cites W1600871831 @default.
• W1912088000 cites W1668553077 @default.
• W1912088000 cites W1675252915 @default.
• W1912088000 cites W1812894901 @default.
• W1912088000 cites W181622342 @default.
• W1912088000 cites W1963569037 @default.
• W1912088000 cites W1968812554 @default.
• W1912088000 cites W1995828159 @default.
• W1912088000 cites W1996241166 @default.
• W1912088000 cites W1998681536 @default.
• W1912088000 cites W2000143497 @default.
• W1912088000 cites W2000384057 @default.
• W1912088000 cites W2003415109 @default.
• W1912088000 cites W2013975343 @default.
• W1912088000 cites W2032275395 @default.
• W1912088000 cites W2032279957 @default.
• W1912088000 cites W2039313371 @default.
• W1912088000 cites W2060579461 @default.
• W1912088000 cites W2063080712 @default.
• W1912088000 cites W2069164250 @default.
• W1912088000 cites W2070149310 @default.
• W1912088000 cites W2077999696 @default.
• W1912088000 cites W2085474307 @default.
• W1912088000 cites W2088189362 @default.
• W1912088000 cites W2088940155 @default.
• W1912088000 cites W2112503578 @default.
• W1912088000 cites W2146923243 @default.
• W1912088000 cites W2155698262 @default.
• W1912088000 cites W2332513141 @default.
• W1912088000 cites W2339539882 @default.
• W1912088000 cites W2420888120 @default.
• W1912088000 cites W362194484 @default.
• W1912088000 cites W4231580378 @default.
• W1912088000 doi "https://doi.org/10.1016/s0021-9258(19)89221-9" @default.
• W1912088000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2937785" @default.
• W1912088000 hasPublicationYear "1986" @default.
• W1912088000 type Work @default.
• W1912088000 sameAs 1912088000 @default.
• W1912088000 citedByCount "66" @default.
• W1912088000 countsByYear W19120880002012 @default.
• W1912088000 countsByYear W19120880002013 @default.
• W1912088000 countsByYear W19120880002017 @default.
• W1912088000 crossrefType "journal-article" @default.
• W1912088000 hasAuthorship W1912088000A5009459466 @default.
• W1912088000 hasAuthorship W1912088000A5047505231 @default.
• W1912088000 hasAuthorship W1912088000A5048301059 @default.
• W1912088000 hasBestOaLocation W19120880001 @default.
• W1912088000 hasConcept C104317684 @default.
• W1912088000 hasConcept C151730666 @default.
• W1912088000 hasConcept C153911025 @default.
• W1912088000 hasConcept C167625842 @default.
• W1912088000 hasConcept C175156509 @default.
• W1912088000 hasConcept C185592680 @default.
• W1912088000 hasConcept C203014093 @default.
• W1912088000 hasConcept C2777292125 @default.
• W1912088000 hasConcept C2779664074 @default.
• W1912088000 hasConcept C3018824666 @default.
• W1912088000 hasConcept C41008148 @default.
• W1912088000 hasConcept C43369102 @default.
• W1912088000 hasConcept C55493867 @default.
• W1912088000 hasConcept C76155785 @default.
• W1912088000 hasConcept C86803240 @default.
• W1912088000 hasConcept C89560881 @default.
• W1912088000 hasConceptScore W1912088000C104317684 @default.
• W1912088000 hasConceptScore W1912088000C151730666 @default.
• W1912088000 hasConceptScore W1912088000C153911025 @default.
• W1912088000 hasConceptScore W1912088000C167625842 @default.
• W1912088000 hasConceptScore W1912088000C175156509 @default.
• W1912088000 hasConceptScore W1912088000C185592680 @default.
• W1912088000 hasConceptScore W1912088000C203014093 @default.
• W1912088000 hasConceptScore W1912088000C2777292125 @default.
• W1912088000 hasConceptScore W1912088000C2779664074 @default.
• W1912088000 hasConceptScore W1912088000C3018824666 @default.
• W1912088000 hasConceptScore W1912088000C41008148 @default.
• W1912088000 hasConceptScore W1912088000C43369102 @default.
• W1912088000 hasConceptScore W1912088000C55493867 @default.
• W1912088000 hasConceptScore W1912088000C76155785 @default.
• W1912088000 hasConceptScore W1912088000C86803240 @default.
• W1912088000 hasConceptScore W1912088000C89560881 @default.
• W1912088000 hasIssue "11" @default.
• W1912088000 hasLocation W19120880001 @default.
• W1912088000 hasOpenAccess W1912088000 @default.
• W1912088000 hasPrimaryLocation W19120880001 @default.
• W1912088000 hasRelatedWork W1523064851 @default.

• next