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- W191240627 abstract "Publisher Summary This chapter presents an electroencephalographic analysis of the convulsant benzodiazepine 1,3-dihydro-5-methyl-2-H-1, 4-benzodiazepine-2-one (Ro 5-3663). The benzodiazepine derivative 1,3-dihydro-5-methyl-2-H-l, 4-benzodiazenine-2-one (Ro 5∼3663), induces convulsions in laboratory animals. While anxiolytic benzodiazepines facilitate GABAergic transmission, Ro 5-3663 impairs this transmission probability by interfering at some steps of the supramolecular organization of the GABAergic receptors. Because of its weak potency in inhibiting the 3H-flunitrazepam binding in membrane homogenate, it has been hypothesized that this drug might not exert its pharmacological effect by acting on the benzodiazepine recognition sites. Drugs that inhibit GABA transmission by acting at postsynaptic sites, such as bicuculline and picrotoxin, induce electroencephalographic (EEG) and behavioral convulsions. The EEG patterns elicited by these drugs consist of three dose related phases: (1) slow waves in the optic cortex, (2) spike-and-waves complexes at the level of sensorimotor cortex, and (3) “grand-mal” generalized seizures. The chapter discusses the EEG effects of the Ro 5-3663 in comparison with the GABA antagonists bicuculline and picrotoxin." @default.
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- W191240627 date "1983-01-01" @default.
- W191240627 modified "2023-09-27" @default.
- W191240627 title "An Electroencephalographic Analysis of the Convulsant Benzodiazepine 1,3-dihydro-5-methyl-2-H-1,4-benzodiazepine-2-one (Ro 5-3663)" @default.
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- W191240627 doi "https://doi.org/10.1016/b978-0-08-029804-7.50029-9" @default.
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