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• W1912449747 endingPage "1052" @default.
• W1912449747 startingPage "1042" @default.
• W1912449747 abstract "Leukocyte Ig-like receptor (LIR) 1 (CD85j/ILT2/LILRB1) is an inhibitory receptor with broad specificity for MHC class I (MHC-I) and the human CMV MHC-I homologue UL18. LIR-1 can inhibit NK cells through the conventional interaction with MHC-I expressed on a target cell (in trans) but the nature and the effects of LIR-1 interactions with MHC-I in cis are not well understood. Here we show that MHC-I expressed in cis has an impact on the detection of LIR-1 with various antibodies. We found the cis interaction alters recognition by only one of two antibodies known to block functional trans recognition by LIR-1 on NK cells. Specifically, we observed an enhancement of recognition with GHI/75 in the presence of various MHC-I alleles on 721.221 cells. We found that blocking the LIR-1 contact site with anti-MHC-I antibodies decreased detection of LIR-1 with GHI/75. We also observed a decrease in GHI/75 following acid denaturation of MHC-I. Finally, disruption of LIR-1 cis interactions with MHC-I significantly enhanced UL18-Fc binding to NK92 cells and enhanced the relative inhibition of NK92 cells by HLA-G. These results have implications for LIR-1 function in scenarios such as infection when MHC-I levels on effector cells may be increased by IFNs." @default.
• W1912449747 created "2016-06-24" @default.
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• W1912449747 date "2013-03-04" @default.
• W1912449747 modified "2023-10-01" @default.
• W1912449747 title "<i>Cis</i>association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18" @default.
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• W1912449747 doi "https://doi.org/10.1002/eji.201242607" @default.
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