FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912555671> ?p ?o ?g. }

• W1912555671 endingPage "68" @default.
• W1912555671 startingPage "63" @default.
• W1912555671 abstract "Summary 1. Tanshinone IIA, one of the active components of the Radix of Salvia miltiorrhiza , is used in traditional Chinese medicine to treat cardiovascular diseases. However, the intracellular mechanism of action of tanshinone IIA remain to be determined. The aims of the present study were to test the hypothesis that tanshinone IIA alters strain‐induced endothelin (ET)‐1 expression and nitric oxide (NO) production, as well as to identify the putative signalling pathways involved, in human umbilical vein endothelial cells (HUVEC). 2. Cultured HUVEC were exposed to cyclic strain in the presence of 1–10 μmol/L tanshinone IIA. Expression of ET‐1 was examined by reverse transcription–polymerase chain reaction and ELISA. Phosphorylation of endothelial NO synthase (eNOS) and activating transcription factor (ATF) 3 was assessed by western blot analysis. 3. Tanshinone IIA (3 and 10 μmol/L) inhibited strain‐induced ET‐1 expression. In contrast, NO production, eNOS phosphorylation and ATF3 expression were enhanced by tanshinone IIA. The eNOS inhibitor N G ‐nitro‐ l‐ arginine methyl ester ( l ‐NAME; 100 μmol/L), the phosphatidylinositol 3‐kinase inhibitor LY294002 (5 μmol/L) and the soluble guanylyl cyclase inhibitor 1H‐[1,2,4] oxadiazolo [4,3‐a] quinoxalin‐1‐one (ODQ; 10 μmol/L) inhibited tanshinone IIA‐induced increases in ATF3 expression. Moreover, treatment of HUVEC with either an NO donor (3,3‐bis [aminoethyl]‐1‐hydroxy‐2‐oxo‐1‐triazene; 500 μmol/L) or an ATF3 activator (carbobenzoxy‐ l ‐leucyl‐ l ‐leucyl‐ l ‐leucinal; 5 μmol/L) resulted in the repression of strain‐induced ET‐1 expression. The inhibitory effect of tanshinone IIA on strain‐induced ET‐1 expression was significantly attenuated by l ‐NAME, ODQ and the transfection of small interfering RNA for ATF3. 4. In conclusion, tanshinone IIA inhibits strain‐induced ET‐1 expression by increasing NO and upregulating ATF3 in HUVEC. The present study provides important new insights into the molecular pathways that may contribute to the beneficial effects of tanshinone IIA in the cardiovascular system." @default.
• W1912555671 created "2016-06-24" @default.
• W1912555671 creator A5000823185 @default.
• W1912555671 creator A5006381864 @default.
• W1912555671 creator A5012679036 @default.
• W1912555671 creator A5023829039 @default.
• W1912555671 creator A5024395820 @default.
• W1912555671 creator A5030904609 @default.
• W1912555671 creator A5043935811 @default.
• W1912555671 creator A5049193093 @default.
• W1912555671 date "2011-12-27" @default.
• W1912555671 modified "2023-10-17" @default.
• W1912555671 title "Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells" @default.
• W1912555671 cites W1607892649 @default.
• W1912555671 cites W1869555064 @default.
• W1912555671 cites W1964526269 @default.
• W1912555671 cites W1964720110 @default.
• W1912555671 cites W1967151011 @default.
• W1912555671 cites W1967767433 @default.
• W1912555671 cites W2022864822 @default.
• W1912555671 cites W2028339911 @default.
• W1912555671 cites W2034602145 @default.
• W1912555671 cites W2040420658 @default.
• W1912555671 cites W2054903963 @default.
• W1912555671 cites W2066794505 @default.
• W1912555671 cites W2072729486 @default.
• W1912555671 cites W2074723035 @default.
• W1912555671 cites W2082341355 @default.
• W1912555671 cites W2087535194 @default.
• W1912555671 cites W2091669203 @default.
• W1912555671 cites W2098296304 @default.
• W1912555671 cites W2103406511 @default.
• W1912555671 cites W2107014487 @default.
• W1912555671 cites W2120955132 @default.
• W1912555671 cites W2142274635 @default.
• W1912555671 cites W2145221987 @default.
• W1912555671 cites W2147069120 @default.
• W1912555671 cites W2160257210 @default.
• W1912555671 cites W2164887790 @default.
• W1912555671 cites W4234401654 @default.
• W1912555671 doi "https://doi.org/10.1111/j.1440-1681.2011.05637.x" @default.
• W1912555671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22032308" @default.
• W1912555671 hasPublicationYear "2011" @default.
• W1912555671 type Work @default.
• W1912555671 sameAs 1912555671 @default.
• W1912555671 citedByCount "15" @default.
• W1912555671 countsByYear W19125556712012 @default.
• W1912555671 countsByYear W19125556712013 @default.
• W1912555671 countsByYear W19125556712014 @default.
• W1912555671 countsByYear W19125556712015 @default.
• W1912555671 countsByYear W19125556712016 @default.
• W1912555671 countsByYear W19125556712017 @default.
• W1912555671 countsByYear W19125556712018 @default.
• W1912555671 countsByYear W19125556712019 @default.
• W1912555671 countsByYear W19125556712022 @default.
• W1912555671 crossrefType "journal-article" @default.
• W1912555671 hasAuthorship W1912555671A5000823185 @default.
• W1912555671 hasAuthorship W1912555671A5006381864 @default.
• W1912555671 hasAuthorship W1912555671A5012679036 @default.
• W1912555671 hasAuthorship W1912555671A5023829039 @default.
• W1912555671 hasAuthorship W1912555671A5024395820 @default.
• W1912555671 hasAuthorship W1912555671A5030904609 @default.
• W1912555671 hasAuthorship W1912555671A5043935811 @default.
• W1912555671 hasAuthorship W1912555671A5049193093 @default.
• W1912555671 hasConcept C11960822 @default.
• W1912555671 hasConcept C142724271 @default.
• W1912555671 hasConcept C149601957 @default.
• W1912555671 hasConcept C153911025 @default.
• W1912555671 hasConcept C170493617 @default.
• W1912555671 hasConcept C178790620 @default.
• W1912555671 hasConcept C185592680 @default.
• W1912555671 hasConcept C188947578 @default.
• W1912555671 hasConcept C202751555 @default.
• W1912555671 hasConcept C204787440 @default.
• W1912555671 hasConcept C2776332195 @default.
• W1912555671 hasConcept C2777411675 @default.
• W1912555671 hasConcept C2777622882 @default.
• W1912555671 hasConcept C2778326061 @default.
• W1912555671 hasConcept C2779934757 @default.
• W1912555671 hasConcept C519581460 @default.
• W1912555671 hasConcept C55493867 @default.
• W1912555671 hasConcept C71924100 @default.
• W1912555671 hasConcept C86803240 @default.
• W1912555671 hasConcept C98274493 @default.
• W1912555671 hasConceptScore W1912555671C11960822 @default.
• W1912555671 hasConceptScore W1912555671C142724271 @default.
• W1912555671 hasConceptScore W1912555671C149601957 @default.
• W1912555671 hasConceptScore W1912555671C153911025 @default.
• W1912555671 hasConceptScore W1912555671C170493617 @default.
• W1912555671 hasConceptScore W1912555671C178790620 @default.
• W1912555671 hasConceptScore W1912555671C185592680 @default.
• W1912555671 hasConceptScore W1912555671C188947578 @default.
• W1912555671 hasConceptScore W1912555671C202751555 @default.
• W1912555671 hasConceptScore W1912555671C204787440 @default.
• W1912555671 hasConceptScore W1912555671C2776332195 @default.
• W1912555671 hasConceptScore W1912555671C2777411675 @default.
• W1912555671 hasConceptScore W1912555671C2777622882 @default.
• W1912555671 hasConceptScore W1912555671C2778326061 @default.

• next