FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912776013> ?p ?o ?g. }

• W1912776013 endingPage "2927" @default.
• W1912776013 startingPage "2915" @default.
• W1912776013 abstract "The Drosophila mushroom body (MB) is a key associative memory center that has also been implicated in the control of sleep. However, the identity of MB neurons underlying homeostatic sleep regulation, as well as the types of sleep signals generated by specific classes of MB neurons, has remained poorly understood. We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep-promoting MBON class and a glutamatergic wake-promoting MBON class. Here, we deploy a combination of neurogenetic, behavioral, and physiological approaches to identify and mechanistically dissect sleep-controlling circuits of the MB. Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic sleep information from different populations of intrinsic MB Kenyon cells (KCs) to specific sleep-regulating MBONs: sleep-promoting KCs increase sleep by preferentially activating the cholinergic MBONs, while wake-promoting KCs decrease sleep by preferentially activating the glutamatergic MBONs. Importantly, activity of the sleep-promoting MB microcircuit is increased by sleep deprivation and is necessary for homeostatic rebound sleep (i.e., the increased sleep that occurs after, and in compensation for, sleep lost during deprivation). These studies reveal for the first time specific functional connections between subsets of KCs and particular MBONs and establish the identity of synaptic microcircuits underlying transmission of homeostatic sleep signals in the MB." @default.
• W1912776013 created "2016-06-24" @default.
• W1912776013 creator A5024679109 @default.
• W1912776013 creator A5038831453 @default.
• W1912776013 creator A5043531661 @default.
• W1912776013 creator A5044530617 @default.
• W1912776013 creator A5061034487 @default.
• W1912776013 creator A5083095804 @default.
• W1912776013 creator A5086255792 @default.
• W1912776013 date "2015-11-01" @default.
• W1912776013 modified "2023-10-14" @default.
• W1912776013 title "Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body" @default.
• W1912776013 cites W1894754493 @default.
• W1912776013 cites W191805265 @default.
• W1912776013 cites W1963958842 @default.
• W1912776013 cites W1966899959 @default.
• W1912776013 cites W1971175217 @default.
• W1912776013 cites W1975881038 @default.
• W1912776013 cites W1978157456 @default.
• W1912776013 cites W1980949515 @default.
• W1912776013 cites W1984841747 @default.
• W1912776013 cites W1985194591 @default.
• W1912776013 cites W1987605400 @default.
• W1912776013 cites W1991194524 @default.
• W1912776013 cites W1998105194 @default.
• W1912776013 cites W1999985543 @default.
• W1912776013 cites W2004739431 @default.
• W1912776013 cites W2014926287 @default.
• W1912776013 cites W2019524885 @default.
• W1912776013 cites W2021892293 @default.
• W1912776013 cites W2034278075 @default.
• W1912776013 cites W2035808397 @default.
• W1912776013 cites W2039939473 @default.
• W1912776013 cites W2043468320 @default.
• W1912776013 cites W2044221124 @default.
• W1912776013 cites W2047483303 @default.
• W1912776013 cites W2051373036 @default.
• W1912776013 cites W2056213320 @default.
• W1912776013 cites W2056240302 @default.
• W1912776013 cites W2069950623 @default.
• W1912776013 cites W2076215193 @default.
• W1912776013 cites W2081610458 @default.
• W1912776013 cites W2086653658 @default.
• W1912776013 cites W2086764165 @default.
• W1912776013 cites W2087331634 @default.
• W1912776013 cites W2088069917 @default.
• W1912776013 cites W2088960975 @default.
• W1912776013 cites W2091070066 @default.
• W1912776013 cites W2092098765 @default.
• W1912776013 cites W2093534366 @default.
• W1912776013 cites W2101427589 @default.
• W1912776013 cites W2117794907 @default.
• W1912776013 cites W2119706891 @default.
• W1912776013 cites W2123607010 @default.
• W1912776013 cites W2127373801 @default.
• W1912776013 cites W2133846434 @default.
• W1912776013 cites W2142667969 @default.
• W1912776013 cites W2145341421 @default.
• W1912776013 cites W2147749026 @default.
• W1912776013 cites W2157991741 @default.
• W1912776013 cites W2171332611 @default.
• W1912776013 doi "https://doi.org/10.1016/j.cub.2015.09.017" @default.
• W1912776013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4654684" @default.
• W1912776013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26455303" @default.
• W1912776013 hasPublicationYear "2015" @default.
• W1912776013 type Work @default.
• W1912776013 sameAs 1912776013 @default.
• W1912776013 citedByCount "121" @default.
• W1912776013 countsByYear W19127760132015 @default.
• W1912776013 countsByYear W19127760132016 @default.
• W1912776013 countsByYear W19127760132017 @default.
• W1912776013 countsByYear W19127760132018 @default.
• W1912776013 countsByYear W19127760132019 @default.
• W1912776013 countsByYear W19127760132020 @default.
• W1912776013 countsByYear W19127760132021 @default.
• W1912776013 countsByYear W19127760132022 @default.
• W1912776013 countsByYear W19127760132023 @default.
• W1912776013 crossrefType "journal-article" @default.
• W1912776013 hasAuthorship W1912776013A5024679109 @default.
• W1912776013 hasAuthorship W1912776013A5038831453 @default.
• W1912776013 hasAuthorship W1912776013A5043531661 @default.
• W1912776013 hasAuthorship W1912776013A5044530617 @default.
• W1912776013 hasAuthorship W1912776013A5061034487 @default.
• W1912776013 hasAuthorship W1912776013A5083095804 @default.
• W1912776013 hasAuthorship W1912776013A5086255792 @default.
• W1912776013 hasBestOaLocation W19127760131 @default.
• W1912776013 hasConcept C104317684 @default.
• W1912776013 hasConcept C111919701 @default.
• W1912776013 hasConcept C112592302 @default.
• W1912776013 hasConcept C121446783 @default.
• W1912776013 hasConcept C169760540 @default.
• W1912776013 hasConcept C170493617 @default.
• W1912776013 hasConcept C17077164 @default.
• W1912776013 hasConcept C200170125 @default.
• W1912776013 hasConcept C22885893 @default.
• W1912776013 hasConcept C2775841894 @default.
• W1912776013 hasConcept C2776038537 @default.
• W1912776013 hasConcept C2778329153 @default.

• next