FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912824737> ?p ?o ?g. }

• W1912824737 endingPage "e0134676" @default.
• W1912824737 startingPage "e0134676" @default.
• W1912824737 abstract "Many epithelial cancers, particularly gastrointestinal tract cancers, remain poor prognosis diseases, due to resistance to cytotoxic therapy and local or metastatic recurrence. We have previously shown that apoptosis incompetent esophageal cancer cells induce autophagy in response to chemotherapeutic agents and this can facilitate their recovery. However, known pharmacological inhibitors of autophagy could not enhance cytotoxicity. In this study, we have examined two well known, clinically approved autophagy inducers, rapamycin and lithium, for their effects on chemosensitivity in apoptosis incompetent cancer cells. Both lithium and rapamycin were shown to induce autophagosomes in esophageal and colorectal cancer cells by western blot analysis of LC3 isoforms, morphology and FACS quantitation of Cyto-ID or mCherry-GFP-LC3. Analysis of autophagic flux indicates inefficient autophagosome processing in lithium treated cells, whereas rapamycin treated cells showed efficient flux. Viability and recovery was assessed by clonogenic assays. When combined with the chemotherapeutic agent 5-fluorouracil, rapamycin was protective. In contrast, lithium showed strong enhancement of non-apoptotic cell death. The combination of lithium with 5-fluorouracil or oxaliplatin was then tested in the syngenic mouse (balb/c) colorectal cancer model--CT26. When either chemotherapeutic agent was combined with lithium a significant reduction in tumor volume was achieved. In addition, survival was dramatically increased in the combination group (p < 0.0001), with > 50% of animals achieving long term cure without re-occurrence (> 1 year tumor free). Thus, combination treatment with lithium can substantially improve the efficacy of chemotherapeutic agents in apoptosis deficient cancer cells. Induction of compromised autophagy may contribute to this cytotoxicity." @default.
• W1912824737 created "2016-06-24" @default.
• W1912824737 creator A5002170676 @default.
• W1912824737 creator A5018389199 @default.
• W1912824737 creator A5047247373 @default.
• W1912824737 creator A5065275381 @default.
• W1912824737 creator A5071871771 @default.
• W1912824737 date "2015-08-06" @default.
• W1912824737 modified "2023-10-06" @default.
• W1912824737 title "Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo" @default.
• W1912824737 cites W1481112428 @default.
• W1912824737 cites W1523693806 @default.
• W1912824737 cites W1603645579 @default.
• W1912824737 cites W1754972901 @default.
• W1912824737 cites W1928236782 @default.
• W1912824737 cites W1964517982 @default.
• W1912824737 cites W1969898574 @default.
• W1912824737 cites W1983788491 @default.
• W1912824737 cites W1983889487 @default.
• W1912824737 cites W1989304353 @default.
• W1912824737 cites W1991222141 @default.
• W1912824737 cites W1994901986 @default.
• W1912824737 cites W1997726546 @default.
• W1912824737 cites W1999012914 @default.
• W1912824737 cites W1999998145 @default.
• W1912824737 cites W2010008722 @default.
• W1912824737 cites W2013075901 @default.
• W1912824737 cites W2014918593 @default.
• W1912824737 cites W2015095309 @default.
• W1912824737 cites W2018447297 @default.
• W1912824737 cites W2020701385 @default.
• W1912824737 cites W2022505166 @default.
• W1912824737 cites W2027306348 @default.
• W1912824737 cites W2029119586 @default.
• W1912824737 cites W2032082659 @default.
• W1912824737 cites W2033433904 @default.
• W1912824737 cites W2048788553 @default.
• W1912824737 cites W2051131116 @default.
• W1912824737 cites W2053766206 @default.
• W1912824737 cites W2054078002 @default.
• W1912824737 cites W2054507046 @default.
• W1912824737 cites W2054936038 @default.
• W1912824737 cites W2055359615 @default.
• W1912824737 cites W2055827129 @default.
• W1912824737 cites W2059773828 @default.
• W1912824737 cites W2061263039 @default.
• W1912824737 cites W2063096082 @default.
• W1912824737 cites W2073133786 @default.
• W1912824737 cites W2078184757 @default.
• W1912824737 cites W2079351077 @default.
• W1912824737 cites W2080506579 @default.
• W1912824737 cites W2086920509 @default.
• W1912824737 cites W2088155937 @default.
• W1912824737 cites W2090831757 @default.
• W1912824737 cites W2094205300 @default.
• W1912824737 cites W2095439279 @default.
• W1912824737 cites W2098985594 @default.
• W1912824737 cites W2102601355 @default.
• W1912824737 cites W2116786011 @default.
• W1912824737 cites W2120188688 @default.
• W1912824737 cites W2125805335 @default.
• W1912824737 cites W2126783165 @default.
• W1912824737 cites W2129497280 @default.
• W1912824737 cites W2132052921 @default.
• W1912824737 cites W2135794202 @default.
• W1912824737 cites W2136703555 @default.
• W1912824737 cites W2141139180 @default.
• W1912824737 cites W2145084709 @default.
• W1912824737 cites W2145822917 @default.
• W1912824737 cites W2147759897 @default.
• W1912824737 cites W2160892460 @default.
• W1912824737 cites W2163294242 @default.
• W1912824737 cites W2164778558 @default.
• W1912824737 cites W2164943291 @default.
• W1912824737 cites W2165316137 @default.
• W1912824737 cites W2165681578 @default.
• W1912824737 cites W2185709237 @default.
• W1912824737 cites W2315474797 @default.
• W1912824737 cites W2318110554 @default.
• W1912824737 cites W2334966517 @default.
• W1912824737 cites W2743254891 @default.
• W1912824737 cites W4238843411 @default.
• W1912824737 doi "https://doi.org/10.1371/journal.pone.0134676" @default.
• W1912824737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4527721" @default.
• W1912824737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26248051" @default.
• W1912824737 hasPublicationYear "2015" @default.
• W1912824737 type Work @default.
• W1912824737 sameAs 1912824737 @default.
• W1912824737 citedByCount "29" @default.
• W1912824737 countsByYear W19128247372016 @default.
• W1912824737 countsByYear W19128247372017 @default.
• W1912824737 countsByYear W19128247372018 @default.
• W1912824737 countsByYear W19128247372019 @default.
• W1912824737 countsByYear W19128247372020 @default.
• W1912824737 countsByYear W19128247372021 @default.
• W1912824737 countsByYear W19128247372022 @default.
• W1912824737 countsByYear W19128247372023 @default.
• W1912824737 crossrefType "journal-article" @default.

• next