Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912880470> ?p ?o ?g. }
- W1912880470 endingPage "20104" @default.
- W1912880470 startingPage "20095" @default.
- W1912880470 abstract "Although chitosan and its derivatives have been frequently utilized as delivery vehicles for small interfering RNA (siRNA), it is challenging to improve the gene silencing efficiency of chitosan-based nanoparticles. In this study, we hypothesized that controlling the spacer arm length between a cell-penetrating peptide (CPP) and a nanoparticle could be critical to enhancing the cellular uptake as well as the gene silencing efficiency of conventional chitosan/siRNA nanoparticles. A peptide consisting of nine arginine units (R9) was used as a CPP, and the spacer arm length was controlled by varying the number of glycine units between the peptide (R9Gn) and the nanoparticle (n = 0, 4, and 10). Various physicochemical characteristics of R9Gn-chitosan/siRNA nanoparticles were investigated in vitro. Increasing the spacing arm length did not significantly affect the complex formation between R9Gn-chitosan and siRNA. However, R9G10-chitosan was much more effective in delivering genes both in vitro and in vivo compared with non-modified chitosan (without the peptide) and R9-chitosan (without the spacer arm). Chitosan derivatives modified with oligoarginine containing a spacer arm can be considered as potential delivery vehicles for various genes." @default.
- W1912880470 created "2016-06-24" @default.
- W1912880470 creator A5010121437 @default.
- W1912880470 creator A5014936129 @default.
- W1912880470 creator A5016293728 @default.
- W1912880470 creator A5029687263 @default.
- W1912880470 creator A5038711100 @default.
- W1912880470 date "2015-01-01" @default.
- W1912880470 modified "2023-09-26" @default.
- W1912880470 title "The spacer arm length in cell-penetrating peptides influences chitosan/siRNA nanoparticle delivery for pulmonary inflammation treatment" @default.
- W1912880470 cites W1609951617 @default.
- W1912880470 cites W1965340954 @default.
- W1912880470 cites W1969140160 @default.
- W1912880470 cites W1972729210 @default.
- W1912880470 cites W1995701404 @default.
- W1912880470 cites W1995884589 @default.
- W1912880470 cites W2001683864 @default.
- W1912880470 cites W2004356674 @default.
- W1912880470 cites W2006893840 @default.
- W1912880470 cites W2010623552 @default.
- W1912880470 cites W2014356856 @default.
- W1912880470 cites W2018369626 @default.
- W1912880470 cites W2022093429 @default.
- W1912880470 cites W2025488297 @default.
- W1912880470 cites W2025857959 @default.
- W1912880470 cites W2026527549 @default.
- W1912880470 cites W2029766213 @default.
- W1912880470 cites W2031636921 @default.
- W1912880470 cites W2033815220 @default.
- W1912880470 cites W2038469051 @default.
- W1912880470 cites W2040237389 @default.
- W1912880470 cites W2044074008 @default.
- W1912880470 cites W2046893115 @default.
- W1912880470 cites W2047598336 @default.
- W1912880470 cites W2054720910 @default.
- W1912880470 cites W2063926115 @default.
- W1912880470 cites W2068858471 @default.
- W1912880470 cites W2076321231 @default.
- W1912880470 cites W2078057254 @default.
- W1912880470 cites W2086514756 @default.
- W1912880470 cites W2086731246 @default.
- W1912880470 cites W2087260141 @default.
- W1912880470 cites W2088654227 @default.
- W1912880470 cites W2088849426 @default.
- W1912880470 cites W2093198351 @default.
- W1912880470 cites W2093980617 @default.
- W1912880470 cites W2111605241 @default.
- W1912880470 cites W2117698690 @default.
- W1912880470 cites W2121258604 @default.
- W1912880470 cites W2160251401 @default.
- W1912880470 cites W2160679630 @default.
- W1912880470 cites W2166915947 @default.
- W1912880470 cites W2315109779 @default.
- W1912880470 doi "https://doi.org/10.1039/c5nr06903c" @default.
- W1912880470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26568525" @default.
- W1912880470 hasPublicationYear "2015" @default.
- W1912880470 type Work @default.
- W1912880470 sameAs 1912880470 @default.
- W1912880470 citedByCount "31" @default.
- W1912880470 countsByYear W19128804702016 @default.
- W1912880470 countsByYear W19128804702017 @default.
- W1912880470 countsByYear W19128804702018 @default.
- W1912880470 countsByYear W19128804702019 @default.
- W1912880470 countsByYear W19128804702020 @default.
- W1912880470 countsByYear W19128804702021 @default.
- W1912880470 countsByYear W19128804702022 @default.
- W1912880470 countsByYear W19128804702023 @default.
- W1912880470 crossrefType "journal-article" @default.
- W1912880470 hasAuthorship W1912880470A5010121437 @default.
- W1912880470 hasAuthorship W1912880470A5014936129 @default.
- W1912880470 hasAuthorship W1912880470A5016293728 @default.
- W1912880470 hasAuthorship W1912880470A5029687263 @default.
- W1912880470 hasAuthorship W1912880470A5038711100 @default.
- W1912880470 hasConcept C104317684 @default.
- W1912880470 hasConcept C119056186 @default.
- W1912880470 hasConcept C12554922 @default.
- W1912880470 hasConcept C150903083 @default.
- W1912880470 hasConcept C155672457 @default.
- W1912880470 hasConcept C166703698 @default.
- W1912880470 hasConcept C171250308 @default.
- W1912880470 hasConcept C185592680 @default.
- W1912880470 hasConcept C192562407 @default.
- W1912880470 hasConcept C202751555 @default.
- W1912880470 hasConcept C207001950 @default.
- W1912880470 hasConcept C22615655 @default.
- W1912880470 hasConcept C2776929087 @default.
- W1912880470 hasConcept C2779281246 @default.
- W1912880470 hasConcept C2779732960 @default.
- W1912880470 hasConcept C54009773 @default.
- W1912880470 hasConcept C55493867 @default.
- W1912880470 hasConcept C67705224 @default.
- W1912880470 hasConcept C86803240 @default.
- W1912880470 hasConceptScore W1912880470C104317684 @default.
- W1912880470 hasConceptScore W1912880470C119056186 @default.
- W1912880470 hasConceptScore W1912880470C12554922 @default.
- W1912880470 hasConceptScore W1912880470C150903083 @default.
- W1912880470 hasConceptScore W1912880470C155672457 @default.
- W1912880470 hasConceptScore W1912880470C166703698 @default.