FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1912979861> ?p ?o ?g. }

• W1912979861 endingPage "4866" @default.
• W1912979861 startingPage "4854" @default.
• W1912979861 abstract "125I-Bolton-Hunter sulfated cholecystokinin-8 was used to localize and characterize cholecystokinin (CCK) receptor binding sites in trigeminal and dorsal root ganglia, and in the spinal cord of the rat, rabbit, and monkey. In the rabbit and monkey, a substantial number, 90 +/- 21% and 24 +/- 8%, respectively, of trigeminal and dorsal root ganglion neurons express CCK binding sites. In the spinal cord, the highest concentration of CCK receptors is found in laminae I and II, which is the major termination site of dorsal root ganglia neurons expressing CCK receptor binding sites. Neonatal capsaicin treatment of the rat results in a 70% decline in CCK receptor binding sites in laminae I and II of the spinal cord, indicating that dorsal root ganglia neurons are a major source of CCK receptors in the spinal cord. Pharmacological experiments using selective CCK-A and CCK-B receptor antagonists demonstrate that CCK-B is the prominent CCK receptor subtype in trigeminal and dorsal root ganglia neurons in the rat, rabbit, and monkey. In the rat and rabbit spinal cord, CCK-B binding sites are the prominent subtype, whereas in the monkey cord, CCK-A is the prominent receptor subtype. These results demonstrate that CCK-B receptors are expressed by a substantial percentage of dorsal root ganglion neurons at all spinal levels, and that CCK may antagonize opiate analgesia at the level of the primary afferent neuron itself." @default.
• W1912979861 created "2016-06-24" @default.
• W1912979861 creator A5008607830 @default.
• W1912979861 creator A5057151848 @default.
• W1912979861 creator A5067091839 @default.
• W1912979861 creator A5075618634 @default.
• W1912979861 creator A5089025232 @default.
• W1912979861 date "1992-12-01" @default.
• W1912979861 modified "2023-09-25" @default.
• W1912979861 title "Trigeminal and dorsal root ganglion neurons express CCK receptor binding sites in the rat, rabbit, and monkey: possible site of opiate- CCK analgesic interactions" @default.
• W1912979861 cites W1842060488 @default.
• W1912979861 cites W1911541716 @default.
• W1912979861 cites W1967565278 @default.
• W1912979861 cites W1969943993 @default.
• W1912979861 cites W1973724319 @default.
• W1912979861 cites W1976632666 @default.
• W1912979861 cites W1977223194 @default.
• W1912979861 cites W1984626572 @default.
• W1912979861 cites W1999399891 @default.
• W1912979861 cites W2001768751 @default.
• W1912979861 cites W2009564734 @default.
• W1912979861 cites W2011979911 @default.
• W1912979861 cites W2012094079 @default.
• W1912979861 cites W2027119507 @default.
• W1912979861 cites W2036483598 @default.
• W1912979861 cites W2037773323 @default.
• W1912979861 cites W2039448661 @default.
• W1912979861 cites W2041106058 @default.
• W1912979861 cites W2041802180 @default.
• W1912979861 cites W2042636262 @default.
• W1912979861 cites W2053358615 @default.
• W1912979861 cites W2054659326 @default.
• W1912979861 cites W2065948718 @default.
• W1912979861 cites W2068290015 @default.
• W1912979861 cites W2070370133 @default.
• W1912979861 cites W2071666492 @default.
• W1912979861 cites W2073256803 @default.
• W1912979861 cites W2074278835 @default.
• W1912979861 cites W2078962110 @default.
• W1912979861 cites W2079345702 @default.
• W1912979861 cites W2079728234 @default.
• W1912979861 cites W2081704409 @default.
• W1912979861 cites W2083822397 @default.
• W1912979861 cites W2089530533 @default.
• W1912979861 cites W2092471855 @default.
• W1912979861 cites W2092635728 @default.
• W1912979861 cites W2094969487 @default.
• W1912979861 cites W2137431985 @default.
• W1912979861 cites W2288324884 @default.
• W1912979861 cites W2399367266 @default.
• W1912979861 cites W2461723826 @default.
• W1912979861 doi "https://doi.org/10.1523/jneurosci.12-12-04854.1992" @default.
• W1912979861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6575773" @default.
• W1912979861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1334505" @default.
• W1912979861 hasPublicationYear "1992" @default.
• W1912979861 type Work @default.
• W1912979861 sameAs 1912979861 @default.
• W1912979861 citedByCount "100" @default.
• W1912979861 countsByYear W19129798612012 @default.
• W1912979861 countsByYear W19129798612013 @default.
• W1912979861 countsByYear W19129798612014 @default.
• W1912979861 countsByYear W19129798612017 @default.
• W1912979861 countsByYear W19129798612018 @default.
• W1912979861 countsByYear W19129798612019 @default.
• W1912979861 countsByYear W19129798612020 @default.
• W1912979861 countsByYear W19129798612021 @default.
• W1912979861 countsByYear W19129798612022 @default.
• W1912979861 crossrefType "journal-article" @default.
• W1912979861 hasAuthorship W1912979861A5008607830 @default.
• W1912979861 hasAuthorship W1912979861A5057151848 @default.
• W1912979861 hasAuthorship W1912979861A5067091839 @default.
• W1912979861 hasAuthorship W1912979861A5075618634 @default.
• W1912979861 hasAuthorship W1912979861A5089025232 @default.
• W1912979861 hasBestOaLocation W19129798611 @default.
• W1912979861 hasConcept C105702510 @default.
• W1912979861 hasConcept C107539642 @default.
• W1912979861 hasConcept C126322002 @default.
• W1912979861 hasConcept C134018914 @default.
• W1912979861 hasConcept C169760540 @default.
• W1912979861 hasConcept C170493617 @default.
• W1912979861 hasConcept C2776281502 @default.
• W1912979861 hasConcept C2776352249 @default.
• W1912979861 hasConcept C2777593968 @default.
• W1912979861 hasConcept C2778794669 @default.
• W1912979861 hasConcept C2780775167 @default.
• W1912979861 hasConcept C2781334511 @default.
• W1912979861 hasConcept C32110497 @default.
• W1912979861 hasConcept C529278444 @default.
• W1912979861 hasConcept C71924100 @default.
• W1912979861 hasConcept C86803240 @default.
• W1912979861 hasConcept C94487597 @default.
• W1912979861 hasConceptScore W1912979861C105702510 @default.
• W1912979861 hasConceptScore W1912979861C107539642 @default.
• W1912979861 hasConceptScore W1912979861C126322002 @default.
• W1912979861 hasConceptScore W1912979861C134018914 @default.
• W1912979861 hasConceptScore W1912979861C169760540 @default.
• W1912979861 hasConceptScore W1912979861C170493617 @default.
• W1912979861 hasConceptScore W1912979861C2776281502 @default.

• next