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- W1913476563 startingPage "1763" @default.
- W1913476563 abstract "Abstract A culture system is described in which 1000 human peripheral blood lymphocytes diluted in 2.5 × 105 mitomycintreated autologous cells respond to phytohemagglutinin (PHA). Proliferation data, including 3HTdR uptake, cell survival counts, and mitotic indices, indicate that this inoculum expands from 1000 to 40,000 cells by day 7, suggesting five or six sequential cell divisions. Chromosome markers in allogeneic cultures demonstrate that the dividing cells are derived from the original 1000 cells and not from the “feeder layer” of mitomycin-treated lymphocytes. The time course of proliferation in this system is similar to that in other human lymphocyte culture systems with a low percentage of responding cells, as in the response to PHA of cells from patients with chronic lymphocytic leukemia or the response of normal lymphocytes to antigens. The conditions provided by the feeder layer which permit proliferation of this small number of lymphocytes are not precisely known, but erythrocytes, heat-killed lymphocytes, or inert particles do not provide a satisfactory substitute." @default.
- W1913476563 created "2016-06-24" @default.
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- W1913476563 date "1977-05-01" @default.
- W1913476563 modified "2023-10-18" @default.
- W1913476563 title "Sequential Proliferation Induced in Human Peripheral Blood Lymphocytes by Mitogen" @default.
- W1913476563 doi "https://doi.org/10.4049/jimmunol.118.5.1763" @default.
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