FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1913614716> ?p ?o ?g. }

• W1913614716 endingPage "1141" @default.
• W1913614716 startingPage "1132" @default.
• W1913614716 abstract "Our previous studies showed that anti‐β 2 M monoclonal antibodies (mAbs) at high doses have direct apoptotic effects on myeloma cells, suggesting that anti‐β 2 M mAbs might be developed as a novel therapeutic agent. In this study, we investigated the ability of the mAbs at much lower concentrations to indirectly kill myeloma cells by utilizing immune effector cells or molecules. Our results showed that anti‐β 2 M mAbs effectively lysed MM cells via antibody‐dependent cell‐mediated cytotoxicity (ADCC) and complement‐dependent cytotoxicity (CDC), which were correlated with and dependent on the surface expression of β 2 M on MM cells. The presence of MM bone marrow stromal cells or addition of IL‐6 did not attenuate anti‐β 2 M mAb‐induced ADCC and CDC activities against MM cells. Furthermore, anti‐β 2 M mAbs only showed limited cytotoxicity toward normal B cells and nontumorous mesenchymal stem cells, indicating that the ADCC and CDC activities of the anti‐β 2 M mAbs were more prone to the tumor cells. Lenalidomide potentiated in vitro ADCC activity against MM cells and in vivo tumor inhibition capacity induced by the anti‐β 2 M mAbs by enhancing the activity of NK cells. These results support clinical development of anti‐β 2 M mAbs, both as a monotherapy and in combination with lenalidomide, to improve MM patient outcome." @default.
• W1913614716 created "2016-06-24" @default.
• W1913614716 creator A5004439239 @default.
• W1913614716 creator A5008895593 @default.
• W1913614716 creator A5020159735 @default.
• W1913614716 creator A5027024676 @default.
• W1913614716 creator A5040279346 @default.
• W1913614716 creator A5043105354 @default.
• W1913614716 creator A5054038404 @default.
• W1913614716 creator A5058744266 @default.
• W1913614716 creator A5063720832 @default.
• W1913614716 creator A5084566787 @default.
• W1913614716 date "2014-02-07" @default.
• W1913614716 modified "2023-10-06" @default.
• W1913614716 title "Anti-β₂M monoclonal antibodies kill myeloma cells<i>via</i>cell- and complement-mediated cytotoxicity" @default.
• W1913614716 cites W1508886423 @default.
• W1913614716 cites W1522278345 @default.
• W1913614716 cites W1599670023 @default.
• W1913614716 cites W1904400501 @default.
• W1913614716 cites W1965962344 @default.
• W1913614716 cites W1966657674 @default.
• W1913614716 cites W1973968158 @default.
• W1913614716 cites W1979343444 @default.
• W1913614716 cites W1982864677 @default.
• W1913614716 cites W1998723026 @default.
• W1913614716 cites W2004543856 @default.
• W1913614716 cites W2006058034 @default.
• W1913614716 cites W2007998678 @default.
• W1913614716 cites W2020793885 @default.
• W1913614716 cites W2021069831 @default.
• W1913614716 cites W2025612305 @default.
• W1913614716 cites W2025807829 @default.
• W1913614716 cites W2030314312 @default.
• W1913614716 cites W2037535526 @default.
• W1913614716 cites W2047832163 @default.
• W1913614716 cites W2061572970 @default.
• W1913614716 cites W2083982805 @default.
• W1913614716 cites W2092246736 @default.
• W1913614716 cites W2099308699 @default.
• W1913614716 cites W2108968802 @default.
• W1913614716 cites W2109638333 @default.
• W1913614716 cites W2110544227 @default.
• W1913614716 cites W2119882516 @default.
• W1913614716 cites W2120316083 @default.
• W1913614716 cites W2122080125 @default.
• W1913614716 cites W2130930654 @default.
• W1913614716 cites W2131340972 @default.
• W1913614716 cites W2137231887 @default.
• W1913614716 cites W2146497768 @default.
• W1913614716 cites W2150903102 @default.
• W1913614716 cites W2151982291 @default.
• W1913614716 cites W2160138194 @default.
• W1913614716 cites W2167288022 @default.
• W1913614716 cites W2168267840 @default.
• W1913614716 cites W2282610461 @default.
• W1913614716 cites W2609515889 @default.
• W1913614716 cites W4237330696 @default.
• W1913614716 cites W53629506 @default.
• W1913614716 doi "https://doi.org/10.1002/ijc.28745" @default.
• W1913614716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230340" @default.
• W1913614716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24474467" @default.
• W1913614716 hasPublicationYear "2014" @default.
• W1913614716 type Work @default.
• W1913614716 sameAs 1913614716 @default.
• W1913614716 citedByCount "7" @default.
• W1913614716 countsByYear W19136147162015 @default.
• W1913614716 countsByYear W19136147162016 @default.
• W1913614716 countsByYear W19136147162017 @default.
• W1913614716 countsByYear W19136147162018 @default.
• W1913614716 countsByYear W19136147162019 @default.
• W1913614716 crossrefType "journal-article" @default.
• W1913614716 hasAuthorship W1913614716A5004439239 @default.
• W1913614716 hasAuthorship W1913614716A5008895593 @default.
• W1913614716 hasAuthorship W1913614716A5020159735 @default.
• W1913614716 hasAuthorship W1913614716A5027024676 @default.
• W1913614716 hasAuthorship W1913614716A5040279346 @default.
• W1913614716 hasAuthorship W1913614716A5043105354 @default.
• W1913614716 hasAuthorship W1913614716A5054038404 @default.
• W1913614716 hasAuthorship W1913614716A5058744266 @default.
• W1913614716 hasAuthorship W1913614716A5063720832 @default.
• W1913614716 hasAuthorship W1913614716A5084566787 @default.
• W1913614716 hasBestOaLocation W19136147161 @default.
• W1913614716 hasConcept C109316439 @default.
• W1913614716 hasConcept C153911025 @default.
• W1913614716 hasConcept C159654299 @default.
• W1913614716 hasConcept C16930146 @default.
• W1913614716 hasConcept C185592680 @default.
• W1913614716 hasConcept C202751555 @default.
• W1913614716 hasConcept C203014093 @default.
• W1913614716 hasConcept C2777726029 @default.
• W1913614716 hasConcept C2780007613 @default.
• W1913614716 hasConcept C40677261 @default.
• W1913614716 hasConcept C502942594 @default.
• W1913614716 hasConcept C542903549 @default.
• W1913614716 hasConcept C55493867 @default.
• W1913614716 hasConcept C86803240 @default.
• W1913614716 hasConceptScore W1913614716C109316439 @default.
• W1913614716 hasConceptScore W1913614716C153911025 @default.

• next