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- W1913906670 abstract "Attempts to modulate brain activity for therapeutic purposes by stimulating various cortical and subcortical areas, have been made since the 19th century. Bartholow was one of the first to describe in detail, a case of brain stimulation in 1874 [13]. However, it was not until a century later, when in 1987, Benabid and Pollack proved that chronic high frequency deep brain stimulation (DBS) of thalamus could be used as a safe and effective way of treating the tremor of Parkinson’s disease (PD) [11,19]. A timeline of important milestones in the history of brain stimulation is shown in Fig. 1. In this article we will discuss the currently approved and the experimental uses of DBS. In addition we will give a brief overview of the proposed mechanisms by which DBS is currently thought to modulate brain activity. Sometimes referred to as a ‘brain pacemaker’, DBS involves placement of intracranial electrodes (Fig. 2) which can be connected to a subcutaneously and subclavicularly implanted pulse generator (IPG). The IPG allows noninvasive adjustments of current amplitude, frequency, pulse width and polarity by means of a hand-" @default.
- W1913906670 created "2016-06-24" @default.
- W1913906670 creator A5012872901 @default.
- W1913906670 creator A5036762247 @default.
- W1913906670 creator A5056665061 @default.
- W1913906670 creator A5059467122 @default.
- W1913906670 date "2008-03-07" @default.
- W1913906670 modified "2023-09-25" @default.
- W1913906670 title "Deep brain stimulation: Treating neurological and psychiatric disorders by modulating brain activity" @default.
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