Matches in SemOpenAlex for { <https://semopenalex.org/work/W191409923> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W191409923 abstract "Background: Observational clinical and ex-vivo studies have established a strong association between atrial fibrillation (AF) and inflammation. However, whether inflammation is cause or consequence of AF and which specific inflammatory mediators increase atrial susceptibility to fibrillate remain elusive. Herein, we provide evidence for mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the pathophysiology of AF. Methods and Results: Patients with AF assessed by pacemaker interrogation not only exhibited higher circulating plasma levels of MPO (503.1 [IR:404.6 –880.7] vs. 437.8 [IR:348.9 – 488.0 pmol/l; p=0.03; n=42), they also revealed an increased MPO burden in explanted left atrial tissue as compared to patients devoid of AF. In AF-patients MPO co-localized with markedly increased formation of 3-nitro and 3-chlorotyrosin, protein oxidations known to be catalyzed by MPO. Myeloperoxidase knock-out mice, pretreated with angiotensin II infusion for 2 weeks yielding increased neutrophil activation, revealed strikingly attenuated vulnerability for AF during right atrial electrophysiological stimulation as compared to wild type mice (probability of AF-induction: 3.0 vs. 12.7%; p<0.01). Whereas the electrical homogeneity of the atrial myocytes was not altered between the groups, atria of MPO knock out mice were indicative of significantly reduced atrial fibrosis and markedly reduced formation of 3-chloro- and 3-nitrotyrosine. Conclusion: In conclusion, the current findings not only underscore the significance of neutrophil activation as a critical pathophysiological prerequisite of AF, but reveal that MPO - by oxidatively modifying protein residues and increasing fibrosis of atrial myocytes - is causally linked to the initiation and perpetuation of AF." @default.
- W191409923 created "2016-06-24" @default.
- W191409923 creator A5001230238 @default.
- W191409923 creator A5006263243 @default.
- W191409923 creator A5008177500 @default.
- W191409923 creator A5008918690 @default.
- W191409923 creator A5031080698 @default.
- W191409923 creator A5036647062 @default.
- W191409923 creator A5053048440 @default.
- W191409923 creator A5065454964 @default.
- W191409923 creator A5068329269 @default.
- W191409923 creator A5072159318 @default.
- W191409923 creator A5076142265 @default.
- W191409923 creator A5079458879 @default.
- W191409923 creator A5087159018 @default.
- W191409923 date "2008-10-28" @default.
- W191409923 modified "2023-10-13" @default.
- W191409923 title "Abstract 3490: Mechanistic Involvement of Myeloperoxidase in the Pathogenesis of Atrial Fibrillation" @default.
- W191409923 doi "https://doi.org/10.1161/circ.118.suppl_18.s_434-c" @default.
- W191409923 hasPublicationYear "2008" @default.
- W191409923 type Work @default.
- W191409923 sameAs 191409923 @default.
- W191409923 citedByCount "0" @default.
- W191409923 crossrefType "journal-article" @default.
- W191409923 hasAuthorship W191409923A5001230238 @default.
- W191409923 hasAuthorship W191409923A5006263243 @default.
- W191409923 hasAuthorship W191409923A5008177500 @default.
- W191409923 hasAuthorship W191409923A5008918690 @default.
- W191409923 hasAuthorship W191409923A5031080698 @default.
- W191409923 hasAuthorship W191409923A5036647062 @default.
- W191409923 hasAuthorship W191409923A5053048440 @default.
- W191409923 hasAuthorship W191409923A5065454964 @default.
- W191409923 hasAuthorship W191409923A5068329269 @default.
- W191409923 hasAuthorship W191409923A5072159318 @default.
- W191409923 hasAuthorship W191409923A5076142265 @default.
- W191409923 hasAuthorship W191409923A5079458879 @default.
- W191409923 hasAuthorship W191409923A5087159018 @default.
- W191409923 hasConcept C10162356 @default.
- W191409923 hasConcept C126322002 @default.
- W191409923 hasConcept C134018914 @default.
- W191409923 hasConcept C150903083 @default.
- W191409923 hasConcept C203565725 @default.
- W191409923 hasConcept C207001950 @default.
- W191409923 hasConcept C2776914184 @default.
- W191409923 hasConcept C2777622882 @default.
- W191409923 hasConcept C2779161974 @default.
- W191409923 hasConcept C2779385521 @default.
- W191409923 hasConcept C2780942790 @default.
- W191409923 hasConcept C519581460 @default.
- W191409923 hasConcept C71924100 @default.
- W191409923 hasConcept C86803240 @default.
- W191409923 hasConceptScore W191409923C10162356 @default.
- W191409923 hasConceptScore W191409923C126322002 @default.
- W191409923 hasConceptScore W191409923C134018914 @default.
- W191409923 hasConceptScore W191409923C150903083 @default.
- W191409923 hasConceptScore W191409923C203565725 @default.
- W191409923 hasConceptScore W191409923C207001950 @default.
- W191409923 hasConceptScore W191409923C2776914184 @default.
- W191409923 hasConceptScore W191409923C2777622882 @default.
- W191409923 hasConceptScore W191409923C2779161974 @default.
- W191409923 hasConceptScore W191409923C2779385521 @default.
- W191409923 hasConceptScore W191409923C2780942790 @default.
- W191409923 hasConceptScore W191409923C519581460 @default.
- W191409923 hasConceptScore W191409923C71924100 @default.
- W191409923 hasConceptScore W191409923C86803240 @default.
- W191409923 hasIssue "suppl_18" @default.
- W191409923 hasLocation W1914099231 @default.
- W191409923 hasOpenAccess W191409923 @default.
- W191409923 hasPrimaryLocation W1914099231 @default.
- W191409923 hasRelatedWork W108763567 @default.
- W191409923 hasRelatedWork W1596130891 @default.
- W191409923 hasRelatedWork W1921209813 @default.
- W191409923 hasRelatedWork W2015011638 @default.
- W191409923 hasRelatedWork W2070734630 @default.
- W191409923 hasRelatedWork W2076526863 @default.
- W191409923 hasRelatedWork W2141842580 @default.
- W191409923 hasRelatedWork W2367275075 @default.
- W191409923 hasRelatedWork W2412953855 @default.
- W191409923 hasRelatedWork W2583538178 @default.
- W191409923 hasRelatedWork W2744653293 @default.
- W191409923 hasRelatedWork W2771280584 @default.
- W191409923 hasRelatedWork W2800880207 @default.
- W191409923 hasRelatedWork W2895072066 @default.
- W191409923 hasRelatedWork W2918302364 @default.
- W191409923 hasRelatedWork W2948567063 @default.
- W191409923 hasRelatedWork W3029229602 @default.
- W191409923 hasRelatedWork W3113196668 @default.
- W191409923 hasRelatedWork W3194555507 @default.
- W191409923 hasRelatedWork W829939689 @default.
- W191409923 hasVolume "118" @default.
- W191409923 isParatext "false" @default.
- W191409923 isRetracted "false" @default.
- W191409923 magId "191409923" @default.
- W191409923 workType "article" @default.