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• W1914160053 abstract "The implementation of continuous manufacturing in the pharmaceutical industry has been of increasing interest over the last years. This chapter focuses on continuous hot melt extrusion (HME) processing as well as on the continuous downstream options that are available. Furthermore, process analytical technology (PAT) tools and the integration of such tools in process control environment are presented. In general, real-time pharmaceutical process verification is accomplished by monitoring univariate (temperature, pressure, etc.) and multivariate (spectra, images, etc.) process parameters and quality attributes, to provide an accurate state estimation of the process, required for advanced control strategies. This chapter describes the development and use of such tools for a continuous HME process, monitored with generic sensors and a near-infrared (NIR) spectrometer in real time, using SIPAT (Siemens platform to collect, display and extract process information) and additional components developed as needed." @default.
• W1914160053 created "2016-06-24" @default.
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• W1914160053 date "2013-01-01" @default.
• W1914160053 modified "2023-10-14" @default.
• W1914160053 title "Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process" @default.
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• W1914160053 doi "https://doi.org/10.1007/978-1-4614-8432-5_15" @default.
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