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- W1914304328 abstract "Abstract Vesicular stomatitis virus (VSV) infection rapidly induces IFN-αβ that confers initial survival, whereas long-term protection is mediated by neutralizing IgG responses. Because coadministration of IFN-αβ can enhance Ab responses against soluble Ags, we addressed whether virus-induced IFN-αβ also had an impact on the induction of neutralizing Ab responses. To this end, we generated apathogenic retrovirus-like particles (VLP) displaying the VSV gp (VLP-VSV). Reminiscent of live VSV, VLP-VSV induced VSV-neutralizing IgM responses that switched to IgG in a T help-dependent manner. In type I IFN receptor-deficient (IFNAR−/−) mice, VLP-VSV injection elicited neutralizing IgM, whereas the IgG switch was absent. The lack of subclass switch was associated with a reduced germinal center reaction. Conditional knockout mice with a lymphocyte-specific IFNAR ablation showed normal Ab responses against VLP-VSV, as well as against live VSV. Thus, IFNAR triggering critically promoted the T help-dependent subclass switch of virus-neutralizing Ab responses against VLP-VSV. Interestingly, in the context of VLP-VSV as well as VSV immunization, IFNAR triggering of B lymphocytes did not play a critical role." @default.
- W1914304328 created "2016-06-24" @default.
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- W1914304328 date "2007-05-01" @default.
- W1914304328 modified "2023-10-12" @default.
- W1914304328 title "Vesicular Stomatitis Virus Glycoprotein Displaying Retrovirus-Like Particles Induce a Type I IFN Receptor-Dependent Switch to Neutralizing IgG Antibodies" @default.
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- W1914304328 doi "https://doi.org/10.4049/jimmunol.178.9.5839" @default.
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