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- W191465861 endingPage "40" @default.
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- W191465861 abstract "The original discovery of steroid hormone receptors and essentially all information concerning their interaction and function in target cells have depended on experiments in which a radioactive steroid serves as a marker for the receptor protein to which it binds. The female reproductive tissues, such as uterus, vagina, and anterior pituitary, contain a characteristic estrogen-binding component which was first indicated by their striking ability to take up and retain tritiated hexestrol and estradiol after the administration of physiological doses of these substances to immature animals. This chapter discusses the biochemical mechanism by which the reaction of estradiol and other estrogenic hormones with receptor substances elicits hormonal response has been the subject of extensive investigation. The activated steroid-receptor complex is translocated to the nucleus where it binds to chromatin and in some way modulates RNA synthesis which appears to be characteristically restricted in hormone-dependent tissues." @default.
- W191465861 created "2016-06-24" @default.
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- W191465861 creator A5074069088 @default.
- W191465861 date "1982-01-01" @default.
- W191465861 modified "2023-09-27" @default.
- W191465861 title "Receptors Reconsidered: A 20-Year Perspective" @default.
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