Matches in SemOpenAlex for { <https://semopenalex.org/work/W1914723876> ?p ?o ?g. }
- W1914723876 endingPage "72" @default.
- W1914723876 startingPage "1260" @default.
- W1914723876 abstract "Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to blood group antigens and antigens that are the main barrier to xenogeneic organ transplantation. Herein, we describe the localization of Forssman antigen in guinea pig lungs and kidneys and the consequences of its interaction with antibodies in vitro and in vivo (Forssman reaction). Exposure of cultured guinea pig aortic endothelial cells to Forssman antibodies induced rapid redistribution of antigen-antibody complexes at the cell surface, followed by shedding that occurred by blebbing of plasma membrane as vesicles or fragments, and was associated with disappearance of antigen from the cell surface (antigenic modulation). Guinea pigs surviving frequent intravenous infections of increasing amounts of antibodies, for a total of 20 to 40 lethal doses, developed a partial or complete adaptation to generalized Forssman reaction, and adaptation was associated with partial or complete modulation of Forssman antigen at the surface of the pulmonary and, in minor degree, renal endothelial and epithelial cells. These findings support the hypothesis that modulation of endothelial carbohydrate antigens contributes to adaptation of highly vascularized organs exposed to tolerable levels of allo- or xenoantibodies." @default.
- W1914723876 created "2016-06-24" @default.
- W1914723876 creator A5006856862 @default.
- W1914723876 creator A5022137602 @default.
- W1914723876 creator A5031050884 @default.
- W1914723876 creator A5033501669 @default.
- W1914723876 creator A5034688516 @default.
- W1914723876 creator A5036426575 @default.
- W1914723876 creator A5041139639 @default.
- W1914723876 creator A5045969631 @default.
- W1914723876 creator A5066993794 @default.
- W1914723876 creator A5076407764 @default.
- W1914723876 date "1995-05-01" @default.
- W1914723876 modified "2023-09-27" @default.
- W1914723876 title "Interaction of antibody with Forssman antigen in guinea pigs. A mechanism of adaptation to antibody- and complement-mediated injury." @default.
- W1914723876 cites W126114442 @default.
- W1914723876 cites W1498685946 @default.
- W1914723876 cites W1551180853 @default.
- W1914723876 cites W1602923580 @default.
- W1914723876 cites W1673395910 @default.
- W1914723876 cites W1953857419 @default.
- W1914723876 cites W1972873143 @default.
- W1914723876 cites W1991071771 @default.
- W1914723876 cites W1996856852 @default.
- W1914723876 cites W2000744856 @default.
- W1914723876 cites W2001452322 @default.
- W1914723876 cites W2010057936 @default.
- W1914723876 cites W2018289835 @default.
- W1914723876 cites W2034287697 @default.
- W1914723876 cites W2042248138 @default.
- W1914723876 cites W2043813535 @default.
- W1914723876 cites W2048769067 @default.
- W1914723876 cites W2048792813 @default.
- W1914723876 cites W2063070220 @default.
- W1914723876 cites W2064835686 @default.
- W1914723876 cites W2078854426 @default.
- W1914723876 cites W2081126815 @default.
- W1914723876 cites W2084279863 @default.
- W1914723876 cites W2084976001 @default.
- W1914723876 cites W2085403237 @default.
- W1914723876 cites W2087066268 @default.
- W1914723876 cites W2100837269 @default.
- W1914723876 cites W2122356287 @default.
- W1914723876 cites W2140250375 @default.
- W1914723876 cites W2146821092 @default.
- W1914723876 cites W2148591507 @default.
- W1914723876 cites W2153450637 @default.
- W1914723876 cites W2156855152 @default.
- W1914723876 cites W2160436707 @default.
- W1914723876 cites W2172252610 @default.
- W1914723876 cites W2178567519 @default.
- W1914723876 cites W2321848601 @default.
- W1914723876 cites W2334886655 @default.
- W1914723876 cites W2400698383 @default.
- W1914723876 cites W2412954019 @default.
- W1914723876 cites W2414768669 @default.
- W1914723876 cites W2414815799 @default.
- W1914723876 cites W2415596285 @default.
- W1914723876 cites W2418629013 @default.
- W1914723876 cites W2419491503 @default.
- W1914723876 cites W2469622494 @default.
- W1914723876 cites W4235077732 @default.
- W1914723876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1869299" @default.
- W1914723876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7747818" @default.
- W1914723876 hasPublicationYear "1995" @default.
- W1914723876 type Work @default.
- W1914723876 sameAs 1914723876 @default.
- W1914723876 citedByCount "6" @default.
- W1914723876 countsByYear W19147238762023 @default.
- W1914723876 crossrefType "journal-article" @default.
- W1914723876 hasAuthorship W1914723876A5006856862 @default.
- W1914723876 hasAuthorship W1914723876A5022137602 @default.
- W1914723876 hasAuthorship W1914723876A5031050884 @default.
- W1914723876 hasAuthorship W1914723876A5033501669 @default.
- W1914723876 hasAuthorship W1914723876A5034688516 @default.
- W1914723876 hasAuthorship W1914723876A5036426575 @default.
- W1914723876 hasAuthorship W1914723876A5041139639 @default.
- W1914723876 hasAuthorship W1914723876A5045969631 @default.
- W1914723876 hasAuthorship W1914723876A5066993794 @default.
- W1914723876 hasAuthorship W1914723876A5076407764 @default.
- W1914723876 hasConcept C126322002 @default.
- W1914723876 hasConcept C134018914 @default.
- W1914723876 hasConcept C147483822 @default.
- W1914723876 hasConcept C153911025 @default.
- W1914723876 hasConcept C159654299 @default.
- W1914723876 hasConcept C203014093 @default.
- W1914723876 hasConcept C2778815084 @default.
- W1914723876 hasConcept C2911091166 @default.
- W1914723876 hasConcept C71924100 @default.
- W1914723876 hasConcept C86803240 @default.
- W1914723876 hasConceptScore W1914723876C126322002 @default.
- W1914723876 hasConceptScore W1914723876C134018914 @default.
- W1914723876 hasConceptScore W1914723876C147483822 @default.
- W1914723876 hasConceptScore W1914723876C153911025 @default.
- W1914723876 hasConceptScore W1914723876C159654299 @default.
- W1914723876 hasConceptScore W1914723876C203014093 @default.
- W1914723876 hasConceptScore W1914723876C2778815084 @default.
- W1914723876 hasConceptScore W1914723876C2911091166 @default.